|
Histiocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.
|
30973282 |
2020 |
|
Neuralgia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Noteworthy, 13 hub genes associated with neuropathic pain and nerve regeneration, including Ccl12, Ppp1r15a, Cdkn1a, Atf3, Nts, Dusp1, Ccl7, Csf, Gadd45a, Serpine1, Timp1 were rarely reported in PubMed database, these genes may provide us the new orientation in experimental research and clinical study.
|
29672183 |
2020 |
|
Otitis Media with Effusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
The changes in the concentrations of MMP-8, MMP-9 and TIMP-1 may indicate an increased remodeling of the extracellular matrix in children with adenoid hypertrophy and otitis media with effusion.
|
31606684 |
2020 |
|
Teratoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, neural stem cell-conditioned medium (NSC-CM) and/or TIMP proteins prevented teratoma growth in vivo.
|
31778275 |
2020 |
|
Tuberculosis, Meningeal
|
0.010 |
Biomarker
|
disease |
BEFREE |
The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.
|
30753686 |
2020 |
|
Hypertrophy of adenoids
|
0.010 |
Biomarker
|
disease |
BEFREE |
The changes in the concentrations of MMP-8, MMP-9 and TIMP-1 may indicate an increased remodeling of the extracellular matrix in children with adenoid hypertrophy and otitis media with effusion.
|
31606684 |
2020 |
|
Joint function disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we aimed to investigate the effect of controlling abnormal joint movement on gait performance and the localization of MMP13 and TIMP-1, using kinematic and histological analyses.
|
29938527 |
2020 |
|
Exudative otitis media
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the current study was to assess the levels of MMP-8, MMP-9 and TIMP-1 in the group of children with adenoids who suffered from exudative otitis media.
|
31606684 |
2020 |
|
Intrahepatic Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we found that the phosphatidylinositol 3-kinase-AKT signal pathway and its downstream effectors, such as tissue inhibitor of metalloproteinases 1 and matrix metallopeptidase 9, were required for MUC13-mediated tumor metastasis of iCCA.
|
31837357 |
2020 |
|
Hashimoto's encephalitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we aimed to evaluate the association of serum matrix metallopeptidase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels with the neurological prognosis of AE.
|
31843295 |
2020 |
|
Histiocytic syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.
|
30973282 |
2020 |
|
Adult Teratoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, neural stem cell-conditioned medium (NSC-CM) and/or TIMP proteins prevented teratoma growth in vivo.
|
31778275 |
2020 |
|
Childhood Teratoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, neural stem cell-conditioned medium (NSC-CM) and/or TIMP proteins prevented teratoma growth in vivo.
|
31778275 |
2020 |
|
Limb ischemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Coexistence of proangiogenic potential and increased MMP-9, TIMP-1, and TIMP-2 levels in the plasma of patients with critical limb ischemia.
|
31273966 |
2020 |
|
Primary cholangiocarcinoma of intrahepatic biliary tract
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, we found that the phosphatidylinositol 3-kinase-AKT signal pathway and its downstream effectors, such as tissue inhibitor of metalloproteinases 1 and matrix metallopeptidase 9, were required for MUC13-mediated tumor metastasis of iCCA.
|
31837357 |
2020 |
|
Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anemia decreased TIMP-1 in rats fed fermented goat milk with Fe overload, whereas there was increased CTGF and MCP-1 in animals fed fermented cow milk with either normal or Fe overload.
|
30014470 |
2019 |
|
Bladder neck obstruction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of MMP-1 was significantly decreased accompanying with increased TIMP-1 expression in BOO rats compared with that in Sham rats, which was ameliorated by SFN treatment.
|
31316719 |
2019 |
|
Malignant neoplasm of larynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to assess the expression of MMP-9 and TIMP-1 in cancerous tissue as well as in the serum and plasma concentrations of these proteins in patients with laryngeal cancer and compare the results to the inflammatory reaction in healthy subjects.
|
31143300 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Background Tissue inhibitor of metalloproteinases-1 ( TIMP -1) and procollagen type III aminoterminal peptide are established circulating markers of extracellular matrix remodeling and associated with cardiovascular disease.
|
30890055 |
2019 |
|
Bronchitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcript expression of pro-inflammatory (CXCL8, IL6, TNF, NFKB), oxidative stress (HMOX1, SOD3, GSTA1, GPx), tissue injury/repair (MMP9/TIMP1) and bronchial cell type markers (MUC5AC, CC10) were assessed using qRT-PCR.Increased secretion of CXCL-8 and MMP-9 markers was detected 24<b> </b>h post-exposure in both PBEC-ALI and PBEC-ALI/CB with more pronounced effect in the later.
|
31462114 |
2019 |
|
Gingivitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis.
|
30626536 |
2019 |
|
liposarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we show that tissue inhibitors of metalloproteinases (TIMPs) from TIMP-1 to TIMP-4 are differently expressed and regulate yes-associated protein (YAP)/transcriptional co-activator with PDZ binding motif (TAZ) in LS.
|
31074490 |
2019 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We performed immunohistochemistry with monoclonal antibodies against MMP-1, MMP-2, MMP-3, MMP-9, and TIMP-1 in 58 kidney-biopsy specimens with LN (according to the 2004 ISN/RPS classification) and eight specimens from normal kidney tissue.
|
30973283 |
2019 |
|
Nodule
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The effect of TIMP1 on pulp cell functions related to hard tissue formation as part of the wound healing process (i.e. biocompatibility, proliferation, differentiation and mineralized nodule formation) was evaluated in vitro and using a direct pulp capping experimental animal model in vivo.
|
30761555 |
2019 |
|
Periapical Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of WNT3, WNT3A and WNT5A in AP tissues was significantly higher than in control tissues, and inversely correlated with the expression of SERPINB1, COL1A1 and TIMP1 (P < 0.05).
|
31831777 |
2019 |