Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 53
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 95
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 65
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 47
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 46
TP63 Q9H3D4 tumor protein p63 Transcription factor 1.00 0.362 0.769 36
HLA-A P04439 major histocompatibility complex, class I, A 1.3E-03 0.370 0.846 34
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 24
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 66
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885 32
TIMP1 P01033 TIMP metallopeptidase inhibitor 1 Enzyme modulator 0.50 0.380 0.885 64
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
S100B P04271 S100 calcium binding protein B Calcium-binding protein 4.4E-02 0.383 0.923 30
CAV1 Q03135 caveolin 1 Enzyme modulator 8.3E-03 0.388 0.885 26
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885 20