Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 95
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 84
CDKN1A P38936 cyclin dependent kinase inhibitor 1A 1.9E-03 0.403 0.769 59
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 53
CDH1 P12830 cadherin 1 0.15 0.401 0.808 50
MKI67 P46013 marker of proliferation Ki-67 1.3E-28 0.431 0.808 38
PLAUR Q03405 plasminogen activator, urokinase receptor 5.3E-03 0.536 0.731 35
HLA-A P04439 major histocompatibility complex, class I, A 1.3E-03 0.370 0.846 34
CDKN2B P42772 cyclin dependent kinase inhibitor 2B 7.3E-03 0.417 0.769 31
ENG P17813 endoglin 1.00 0.446 0.846 28
MGMT P16455 O-6-methylguanine-DNA methyltransferase 1.2E-07 0.412 0.885 28
TNC P24821 tenascin C 1.3E-07 0.433 0.846 26
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 24
CST3 P01034 cystatin C 3.9E-03 0.436 0.808 22
MTRR Q9UBK8 5-methyltetrahydrofolate-homocysteine methyltransferase reductase 2.2E-14 0.502 0.808 19
TOP2A P11388 DNA topoisomerase II alpha 0.99 0.497 0.731 19
CA9 Q16790 carbonic anhydrase 9 1.3E-09 0.483 0.731 19
MTR Q99707 5-methyltetrahydrofolate-homocysteine methyltransferase 2.4E-12 0.482 0.808 18
ELAVL1 Q15717 ELAV like RNA binding protein 1 0.99 0.560 0.731 14
CADM1 Q9BY67 cell adhesion molecule 1 0.66 0.491 0.769 14
ITGA3 P26006 integrin subunit alpha 3 3.6E-07 0.573 0.731 12
NF2 P35240 neurofibromin 2 1.00 0.468 0.885 11
DLC1 Q96QB1 DLC1 Rho GTPase activating protein 1.00 0.529 0.731 9