Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats. 22750969

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Biomarker RGD Erythropoietin attenuates cardiopulmonary bypass-induced renal inflammatory injury by inhibiting nuclear factor-κB p65 expression. 22659586

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 Biomarker RGD Insulin reduces LPS-induced lethality and lung injury in rats. 22982561

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 Biomarker RGD Regulatory effects of endogenous interleukin-1 receptor antagonist protein in immunoglobulin G immune complex-induced lung injury. 8613550

1996

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 Biomarker RGD In vivo effect of surfactant on inflammatory cytokines during endotoxin-induced lung injury in rodents. 21767135

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.210 Biomarker RGD [Effects of hyperbaric oxygen on the acute lung injury induced by oleic acid in rats]. 20663306

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0001849
Disease: AIDS Dementia Complex
AIDS Dementia Complex
0.220 Biomarker RGD Evidence implicating matrix metalloproteinases in the mechanism underlying accumulation of IL-1beta and neuronal apoptosis in the neocortex of HIV/gp120-exposed rats. 17678975

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases
0.230 Biomarker RGD Long-term binge and escalating ethanol exposure causes necroinflammation and fibrosis in rat liver. 23009062

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Biomarker RGD Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway. 22963993

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.600 Therapeutic RGD Potential therapeutic effect of nanobased formulation of rivastigmine on rat model of Alzheimer's disease. 23378761

2013

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003123
Disease: Anorexia
Anorexia
0.530 Biomarker RGD Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats. 22902858

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Anti-Basement Membrane Glomerulonephritis
0.200 Biomarker RGD Intrinsic renal cells are the major source of interleukin-1 beta synthesis in normal and diseased rat kidney. 9198037

1997

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.300 Biomarker RGD A study on immunopathogenetic mechanisms of atherosclerotic process caused by chronic infection of Chlamydia pneumoniae in rats (Ratus novergicus). 17132885

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0751955
Disease: Brain Infarction
Brain Infarction
0.210 Biomarker RGD Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion. 17678971

2007

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0006625
Disease: Cachexia
Cachexia
0.230 Biomarker RGD Effects of aging and cytokine blockade on inflammatory cachexia. 15005009

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly
0.500 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Biomarker RGD Potential protective effect of honey against paracetamol-induced hepatotoxicity. 23102243

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Therapeutic RGD Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats. 29278859

2018

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chemical and Drug Induced Liver Injury
0.500 Therapeutic RGD Ellagic Acid Prevents Oxidative Stress, Inflammation, and Histopathological Alterations in Acrylamide-Induced Hepatotoxicity in Wistar Rats. 31342809

2019

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.280 Biomarker RGD Curcumin and enalapril ameliorate renal failure by antagonizing inflammation in 5/6 nephrectomized rats: role of phospholipase and cyclooxygenase. 22031851

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.280 Biomarker RGD Multiple antioxidants and L-arginine modulate inflammation and dyslipidemia in chronic renal failure rats. 20199183

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Chronic left-sided ulcerative colitis
0.200 Biomarker RGD "[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]." 24812904

2014

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009197
Disease: Cochlear Diseases
Cochlear Diseases
0.200 Therapeutic RGD The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea. 29304389

2018

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009319
Disease: Colitis
Colitis
0.600 Biomarker RGD Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. 22969190

2012

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0010692
Disease: Cystitis
Cystitis
0.240 Biomarker RGD Improvement by phytotherapeutic agent of detrusor overactivity, down-regulation of pharmacological receptors and urinary cytokines in rats with cyclophosphamide induced cystitis. 23000860

2013