Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.600 Biomarker RGD "[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]." 24812904

2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0375359
Disease: Chronic left-sided ulcerative colitis
Chronic left-sided ulcerative colitis 		0.200 Biomarker RGD "[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]." 24812904

2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.300 Biomarker RGD (Pro)renin receptor contributes to diabetic nephropathy by enhancing renal inflammation. 19769609

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection 		0.260 Biomarker RGD UTI complicated with struvite formation was characterized by an exaggerated immune response that was mostly neutrophilic (P <or= 0.0001), with lesions that showed extensive uroepithelial hyperplasia (P <or= 0.0001), and a predominance of IL-1 alpha, IL-1 beta, and GRO/KC in the urine (P <or= 0.02). 19171043

2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0022661
Disease: Kidney Failure, Chronic
Kidney Failure, Chronic 		0.280 Biomarker RGD CRF rats showed increased plasma IL-1 alpha, IL1-beta, IL-6, TNF-alpha, and sICAM-1 levels and decreased anti-inflammatory cytokines IL-4 and 10 levels, hypertension, and dyslipidemia. 20199183

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0243026
Disease: Sepsis
Sepsis 		0.300 Biomarker RGD A model of myocardial inflammation and dysfunction in burn complicated by sepsis. 17529909

2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.300 Biomarker RGD A quantitative study of lung dysfunction following haemorrhagic shock in rats. 20041965

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic 		0.200 ModifyingMutation RGD A quantitative study of p38 mitogen-activated protein kinase on renal dysfunction after hemorrhagic shock in rats. 21336199

2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker RGD A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. 15317861

2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0403416
Disease: Idiopathic crescentic glomerulonephritis
Idiopathic crescentic glomerulonephritis 		0.230 Biomarker RGD A spleen tyrosine kinase inhibitor reduces the severity of established glomerulonephritis. 19959716

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.300 Biomarker RGD A study on immunopathogenetic mechanisms of atherosclerotic process caused by chronic infection of Chlamydia pneumoniae in rats (Ratus novergicus). 17132885

2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0752235
Disease: Lyme Neuroborreliosis
Lyme Neuroborreliosis 		0.200 Biomarker RGD Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis. 23134838

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Therapeutic RGD Acetyl-l-carnitine attenuates arsenic-induced liver injury by abrogation of mitochondrial dysfunction, inflammation, and apoptosis in rats. 29278859

2018
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0243026
Disease: Sepsis
Sepsis 		0.300 Therapeutic RGD Activated protein C alters inflammation and protects renal function in sepsis. 21429520

2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Biomarker RGD Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway. 22963993

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Biomarker RGD alpha-melanocyte-stimulating hormone gene transfer attenuates inflammation after bile duct ligation in the rat. 17676395

2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0029799
Disease: Other specified forms of pleural effusion, except tuberculous
Other specified forms of pleural effusion, except tuberculous 		0.200 Biomarker RGD Anti-inflammation effects of corn silk in a rat model of carrageenin-induced pleurisy. 21898269

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0029799
Disease: Other specified forms of pleural effusion, except tuberculous
Other specified forms of pleural effusion, except tuberculous 		0.200 Biomarker RGD Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. 20141620

2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.300 Biomarker RGD Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson's disease. 23159314

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0520679
Disease: Sleep Apnea, Obstructive
Sleep Apnea, Obstructive 		0.250 Biomarker RGD Biological consequences of oxygen desaturation and respiratory effort in an acute animal model of obstructive sleep apnea (OSA). 19342292

2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Blockade of renin angiotensin system increased resistance to STZ-induced diabetes in rats with long-term high-fat diet. 23197974

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0343387
Disease: Enterocolitis, Neutropenic
Enterocolitis, Neutropenic 		0.200 Biomarker RGD CDP-choline reduces severity of intestinal injury in a neonatal rat model of necrotizing enterocolitis. 23228325

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0010692
Disease: Cystitis
Cystitis 		0.240 Biomarker RGD Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis. 11948286

2002
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.220 Biomarker RGD Changes of inflammatory cytokines and neurotrophins emphasized their roles in hypoxic-ischemic brain damage. 23110519

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0017665
Disease: Membranous glomerulonephritis
Membranous glomerulonephritis 		0.200 Biomarker RGD Corticosteroids worsen proteinuria and increase intraglomerular signaling by NF-ĸB in a model of membranous glomerulonephritis. 20588061

2010