Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Biomarker RGD Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: involvement of Akt/NF-κB pathway. 22963993

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009319
Disease: Colitis
Colitis 		0.600 Biomarker RGD Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. 22969190

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.600 Biomarker RGD "[Exploration of the theory of ""Fei and Dachang being interior-exteriorly related"" from observing changes of inflammatory cytokines and oxygen free radicals in the lung tissue of ulcerative colitis rats]." 24812904

2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.600 Biomarker RGD Reserpine induced behavioral depression partially via brain interleukin-1 beta generation. 15000880

2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0015967
Disease: Fever
Fever 		0.600 Biomarker RGD In conclusion, our results show that ET-1 increases IL-1 production in the POA, and this effect appears to be correlated to ET-1-induced fever in vivo, as well as to PG production in vitro. 16455768

2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker RGD A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. 15317861

2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker RGD Triptolide prevents and attenuates neuropathic pain via inhibiting central immune response. 23159984

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker RGD Peri-sciatic administration of recombinant rat IL-1β induces mechanical allodynia by activation of src-family kinases in spinal microglia in rats. 22265659

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker RGD Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system. 15894892

2005
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 Biomarker RGD Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension. 21173343

2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker RGD Evaluation of the anti-myocardial ischemia effect of individual and combined extracts of Panax notoginseng and Carthamus tinctorius in rats. 23237935

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker RGD Delayed anesthetic preconditioning protects against myocardial infarction via activation of nuclear factor-κB and upregulation of autophagy. 23143013

2013
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.600 Biomarker RGD Early gestational intrauterine infection induces postnatal lung inflammation and arrests lung development in a rat model. 20476872

2011
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.600 Biomarker RGD Modulatory effects of curcumin and green tea extract against experimentally induced pulmonary fibrosis: a comparison with N-acetyl cysteine. 23132788

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.600 Biomarker RGD Phosphodiesterase-5 inhibition by sildenafil citrate in a rat model of bleomycin-induced lung fibrosis. 19945540

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Biomarker RGD alpha-melanocyte-stimulating hormone gene transfer attenuates inflammation after bile duct ligation in the rat. 17676395

2008
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Biomarker RGD Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body. 22994521

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0021368
Disease: Inflammation
Inflammation 		0.570 Biomarker RGD The aim of the present study was to test the hypothesis that IL-1beta mediates the functional consequences of inflammation during the course of delayed-type hypersensitivity response to bacillus Calmette-Guérin (BCG) in the hippocampus of Lewis rats. 15050649

2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.550 Biomarker RGD Renoprotective effect of rosuvastatin in DOCA-salt hypertensive rats. 19948880

2010
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003123
Disease: Anorexia
Anorexia 		0.530 Biomarker RGD Involvement of hypothalamic cyclooxygenase-2, interleukin-1β and melanocortin in the development of docetaxel-induced anorexia in rats. 22902858

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus. 17669395

2007
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker RGD Blockade of renin angiotensin system increased resistance to STZ-induced diabetes in rats with long-term high-fat diet. 23197974

2012
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.500 Biomarker RGD Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. 16886979

2006
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0333355
Disease: Inflammatory disease of mucous membrane
Inflammatory disease of mucous membrane 		0.500 Biomarker RGD Dietary transforming growth factor-beta 2 (TGF-β2) supplementation reduces methotrexate-induced intestinal mucosal injury in a rat. 22984629

2012