×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.
18706089 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.
18930998 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Pathology of breast cancer in women with constitutional CHEK2 mutations.
15803365 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large.16914568 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.
18484200 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.
11967536 2002
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations.
18058223 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant.
15466005 2004
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Absence of CHEK2 1100delC mutation in familial breast cancer cases from a South American population.
17876702 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.
18172190 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
18085035 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.
17705858 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining.
12094328 2002
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.
16671833 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
15649950 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
17721994 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.
18381420 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.
18175216 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study.
18253122 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Increased risk of breast cancer associated with CHEK2*1100delC.
16880452 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic.
15803363 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention.
19021634 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
18725978 2008
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals.
15700044 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency).
15472904 2005