×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large.
16914568
2006
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Absence of CHEK2 1100delC mutation in familial breast cancer cases from a South American population.
17876702
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations.
18058223
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
18557994
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Association between the CHEK2*1100delC germ line mutation and estrogen receptor status.
17010071
2006
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast cancer in patients carrying a germ-line CHEK2 mutation: Outcome after breast conserving surgery and adjuvant radiotherapy.
17250914
2007
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.
18484200
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation.
17132695
2007
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.
17705858
2007
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 1100delC mutation is frequent among Russian breast cancer patients.
16758118
2006
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
18725978
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.
15122511
2004
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.
18172190
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
CHEKs and balances: accounting for breast cancer.
11984555
2002
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
14701743
2004
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation.
16337852
2005
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.
18930998
2009
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Estrogen receptor status in CHEK2-positive breast cancers: implications for chemoprevention.
19021634
2009
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
AlteredExpression
LHGDN
Expression of checkpoint kinase 2 in breast carcinomas: correlation with key regulators of tumor cell proliferation, angiogenesis, and survival.
16437383
2006
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
Family history, genetic testing, and clinical risk prediction: pooled analysis of CHEK2 1100delC in 1,828 bilateral breast cancers and 7,030 controls.
19124502
2009
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining.
12094328
2002
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.
18381420
2008
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
15649950
2005
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts.
17721994
2007
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
18085035
2007