×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.
11967536 2002
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
CHEKs and balances: accounting for breast cancer.
11984555 2002
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Finally, tissue microarray analysis indicated that breast tumors from patients with 1100delC mutations show reduced CHEK2 immunostaining.
12094328 2002
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.
14701743 2004
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Limited relevance of the CHEK2 gene in hereditary breast cancer.
15095295 2004
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.
15122511 2004
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant.
15466005 2004
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
We have here studied CHEK2 protein expression by immunohistochemistry on a tissue microarray of 611 unselected breast tumors and also evaluated the tumor characteristics among 1,297 unselected breast cancer patients defined for the c.1100delC germ line mutation status (2.5% carrier frequency).
15472904 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
15649950 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals.
15700044 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
The CHEK2 c.1100delC germline mutation rarely contributes to breast cancer development in the Czech Republic.
15803363 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Pathology of breast cancer in women with constitutional CHEK2 mutations.
15803365 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation.
16337852 2005
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
AlteredExpression
LHGDN
Expression of checkpoint kinase 2 in breast carcinomas: correlation with key regulators of tumor cell proliferation, angiogenesis, and survival.
16437383 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.
16492927 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk.
16671833 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 1100delC mutation is frequent among Russian breast cancer patients.
16758118 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Increased risk of breast cancer associated with CHEK2*1100delC.
16880452 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast tumors which arise in carriers of CHEK2 mutations seem to be similar to those of breast cancers in the population at large.16914568 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations.
16998498 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
The CHEK2 gene and inherited breast cancer susceptibility.
16998506 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Association between the CHEK2*1100delC germ line mutation and estrogen receptor status.
17010071 2006
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
Biomarker
LHGDN
Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutation.
17132695 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
Breast cancer in patients carrying a germ-line CHEK2 mutation: Outcome after breast conserving surgery and adjuvant radiotherapy.
17250914 2007
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
LHGDN
CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.
17705858 2007