Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 112
Gene Symbol: ADCY6
ADCY6
CUI: C0018801
Disease: Heart failure
Heart failure
0.020 Biomarker LHGDN Adenylylcyclase gene transfer increases function of the failing heart. 17007567

2006

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0018801
Disease: Heart failure
Heart failure
0.380 AlteredExpression LHGDN Although activation of PPARgamma appears to have beneficial effects on atherosclerosis and heart failure, it is still largely uncertain whether PPARgamma ligands prevent the development of cardiovascular diseases. 12861348

2003

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 GeneticVariation LHGDN Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise. 15994241

2005

Entrez Id: 270
Gene Symbol: AMPD1
AMPD1
CUI: C0018801
Disease: Heart failure
Heart failure
0.100 GeneticVariation LHGDN Association of C34T AMPD1 gene polymorphism with features of metabolic syndrome in patients with coronary artery disease or heart failure. 18855224

2009

Entrez Id: 94025
Gene Symbol: MUC16
MUC16
CUI: C0018801
Disease: Heart failure
Heart failure
0.040 Biomarker LHGDN Carbohydrate antigen 125 (CA 125), known as a tumor marker for ovarian cancer, has been reported to increase and relate to severity in heart failure patients with systolic dysfunction. 17285443

2007

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 AlteredExpression LHGDN Cessation of pulmonary and coronary secretion of adrenomedullin peptides in the progression of human heart failure. 11972292

2002

Entrez Id: 8862
Gene Symbol: APLN
APLN
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 AlteredExpression LHGDN Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. 12914775

2003

Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker LHGDN Clinical significance of N-terminal-probrain natriuretic peptide in hypertrophic cardiomyopathy. 17879024

2007

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 Biomarker LHGDN Collectively, these results support a protective role for increased AM in the cardiac hypertrophy and heart failure. 15974887

2005

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. 18068948

2008

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0018801
Disease: Heart failure
Heart failure
0.100 Biomarker LHGDN Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. 16095497

2005

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker LHGDN Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. 16095497

2005

Entrez Id: 2247
Gene Symbol: FGF2
FGF2
CUI: C0018801
Disease: Heart failure
Heart failure
0.020 Biomarker LHGDN Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. 16095497

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 AlteredExpression LHGDN Down-regulation of matrix metalloproteinase-9 (MMP-9) expression in the myocardium of congestive heart failure patients. 17889183

2007

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation LHGDN Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure. 15121491

2004

Entrez Id: 7099
Gene Symbol: TLR4
TLR4
CUI: C0018801
Disease: Heart failure
Heart failure
0.100 AlteredExpression LHGDN Elevated circulating levels of heat shock protein 70 are related to systemic inflammatory reaction through monocyte Toll signal in patients with heart failure after acute myocardial infarction. 16714144

2006

Entrez Id: 10911
Gene Symbol: UTS2
UTS2
CUI: C0018801
Disease: Heart failure
Heart failure
0.060 Biomarker LHGDN Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure. 12791592

2003

Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 GeneticVariation LHGDN Fading sodium channels in failing hearts. 18040022

2007

Entrez Id: 2697
Gene Symbol: GJA1
GJA1
CUI: C0018801
Disease: Heart failure
Heart failure
0.100 AlteredExpression LHGDN Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. 18056766

2008

Entrez Id: 7082
Gene Symbol: TJP1
TJP1
CUI: C0018801
Disease: Heart failure
Heart failure
0.010 AlteredExpression LHGDN Gap junction remodelling in human heart failure is associated with increased interaction of connexin43 with ZO-1. 18056766

2008

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410

2007

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410

2007

Entrez Id: 11188
Gene Symbol: NISCH
NISCH
CUI: C0018801
Disease: Heart failure
Heart failure
0.010 AlteredExpression LHGDN Imidazoline receptors in the heart: characterization, distribution, and regulation. 12021582

2002

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression LHGDN Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. 14729387

2004

Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
CUI: C0018801
Disease: Heart failure
Heart failure
0.340 AlteredExpression LHGDN Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. 14729387

2004