Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure. 18068948

2008

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410

2007

Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation LHGDN Unexplained week-to-week variation in BNP and NT-proBNP is low in chronic heart failure patients during steady state. 16829184

2007

Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker LHGDN Clinical significance of N-terminal-probrain natriuretic peptide in hypertrophic cardiomyopathy. 17879024

2007

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN Gene polymorphism of angiotensin-converting enzyme and angiotensin II type 1 receptor in patients with congestive heart failure. 18767410

2007

Entrez Id: 4879
Gene Symbol: NPPB
NPPB
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN [BNP tests in the emergency department to diagnose congestive heart failure]. 17086116

2006

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker LHGDN Differential role of TGF-beta1/bFGF and ET-1 in graft fibrosis in heart failure patients. 16095497

2005

Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 GeneticVariation LHGDN Effects of ACE gene insertion/deletion polymorphism on response to spironolactone in patients with chronic heart failure. 15121491

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 Biomarker LHGDN TNFalpha in patients with congestive heart failure. 14685701

2004

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN [The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients]. 12133434

2002

Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018801
Disease: Heart failure
Heart failure
0.600 AlteredExpression LHGDN [Gene expression of Ang II receptors in myocardium in congestive heart failure]. 12133421

2002

Entrez Id: 1909
Gene Symbol: EDNRA
EDNRA
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression LHGDN Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. 14729387

2004

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0018801
Disease: Heart failure
Heart failure
0.380 AlteredExpression LHGDN Although activation of PPARgamma appears to have beneficial effects on atherosclerosis and heart failure, it is still largely uncertain whether PPARgamma ligands prevent the development of cardiovascular diseases. 12861348

2003

Entrez Id: 6548
Gene Symbol: SLC9A1
SLC9A1
CUI: C0018801
Disease: Heart failure
Heart failure
0.360 AlteredExpression LHGDN We conclude that activation of NHE1 is sufficient to initiate cardiac hypertrophy and heart failure mainly through activation of CaMKII-histone deacetylase pathway. 18776042

2008

Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
CUI: C0018801
Disease: Heart failure
Heart failure
0.340 AlteredExpression LHGDN Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. 14729387

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 Biomarker LHGDN Thus, p53 is a key molecule which triggers the development of heart failure from multiple mechanisms. 18464525

2008

Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 GeneticVariation LHGDN Fading sodium channels in failing hearts. 18040022

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 AlteredExpression LHGDN Down-regulation of matrix metalloproteinase-9 (MMP-9) expression in the myocardium of congestive heart failure patients. 17889183

2007

Entrez Id: 6331
Gene Symbol: SCN5A
SCN5A
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 GeneticVariation LHGDN Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. 15671429

2005

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 Biomarker LHGDN Collectively, these results support a protective role for increased AM in the cardiac hypertrophy and heart failure. 15974887

2005

Entrez Id: 154
Gene Symbol: ADRB2
ADRB2
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 GeneticVariation LHGDN Arg16/Gly beta2-adrenergic receptor polymorphism alters the cardiac output response to isometric exercise. 15994241

2005

Entrez Id: 8862
Gene Symbol: APLN
APLN
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 AlteredExpression LHGDN Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure. 12914775

2003

Entrez Id: 5350
Gene Symbol: PLN
PLN
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 GeneticVariation LHGDN Transgenic PLN(R9C) mice recapitulated human heart failure with premature death. 12610310

2003

Entrez Id: 133
Gene Symbol: ADM
ADM
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 AlteredExpression LHGDN Cessation of pulmonary and coronary secretion of adrenomedullin peptides in the progression of human heart failure. 11972292

2002

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0018801
Disease: Heart failure
Heart failure
0.280 AlteredExpression LHGDN We conducted this study to investigate the effects of fluvastatin therapy on plasma IL-10 cytokine concentration in patients with HF. 18923248

2008