×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Rheumatoid arthritis patients showed high TNFalpha mRNA expression (1.33-fold).18797411 2008
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus.
15641066 2005
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
15208781 2004
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis.
18156150 2008
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population.
17133579 2006
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution?
16446172 2006
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material.
17661906 2007
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.
16380915 2005
×
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.
18087673 2008
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis.
17436241 2007
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility.
18381799 2008
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.
16507117 2006
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
AlteredExpression
LHGDN
Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis.
16820934 2006
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Tumor necrosis factor-alpha -308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans.
15725578 2005
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
AlteredExpression
LHGDN
Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor.
18668547 2008
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
[Role of TNF-alpha and cytokines in the physiopathology of rheumatoid arthritis. Therapeutic perspectives].
14979058 2003
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
19017992 2008
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: evidence for an early onset/disease severity effect.
15641088 2005
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population.
17562093 2008
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis.
17343250 2007
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.
17135225 2007
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
AlteredExpression
LHGDN
JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha.
16936264 2006
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1 beta and tumor necrosis factor.
15723199 2005
×
Entrez Id: 6583
Gene Symbol: SLC22A4
SLC22A4
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis.
14608356 2003
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
AlteredExpression
LHGDN
Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
16564576 2006