×
Entrez Id: 4552
Gene Symbol: MTRR
MTRR
Rheumatoid Arthritis
0.030
GeneticVariation
LHGDN
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis.
17611986 2007
×
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
Rheumatoid Arthritis
0.400
GeneticVariation
LHGDN
677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis.
18034620 2007
×
Entrez Id: 847
Gene Symbol: CAT
CAT
Rheumatoid Arthritis
0.400
AlteredExpression
LHGDN
RA patients exhibited an increasing CAT and SOD activity in their sera (p<0.05) with a positive correlation observed between CAT and IgG anti-CAT (p<0.05).18415766 2008
×
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
Rheumatoid Arthritis
0.020
GeneticVariation
LHGDN
RA patients who carry the rs1800541-rs5370 T-T EDN1 haplotype appear more likely to be hypertensive with an increased SBP and PP.18663623 2008
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
Rheumatoid arthritis patients showed high TNFalpha mRNA expression (1.33-fold).18797411 2008
×
Entrez Id: 50604
Gene Symbol: IL20
IL20
Rheumatoid Arthritis
0.100
Biomarker
LHGDN
IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients.18061474 2008
×
Entrez Id: 4050
Gene Symbol: LTB
LTB
Rheumatoid Arthritis
0.030
Biomarker
LHGDN
LT-Beta may play a role in RA disease pathogenesis by contributing to a more intense inflammatory reaction in the synovium.18379788 2008
×
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
Rheumatoid Arthritis
0.100
GeneticVariation
LHGDN
A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis.
12846053 2003
×
Entrez Id: 7185
Gene Symbol: TRAF1
TRAF1
Rheumatoid Arthritis
0.500
GeneticVariation
LHGDN
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
17880261 2007
×
Entrez Id: 727
Gene Symbol: C5
C5
Rheumatoid Arthritis
0.160
GeneticVariation
LHGDN
A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis.
17880261 2007
×
Entrez Id: 4689
Gene Symbol: NCF4
NCF4
Rheumatoid Arthritis
0.010
GeneticVariation
LHGDN
A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.
17897462 2007
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
Rheumatoid Arthritis
0.400
AlteredExpression
LHGDN
A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls.
18040764 2008
×
Entrez Id: 5027
Gene Symbol: P2RX7
P2RX7
Rheumatoid Arthritis
0.070
AlteredExpression
LHGDN
A comparative study of interleukin-1beta production and p2x7 expression after ATP stimulation by peripheral blood mononuclear cells isolated from rheumatoid arthritis patients and normal healthy controls.
18040764 2008
×
Entrez Id: 4282
Gene Symbol: MIF
MIF
Rheumatoid Arthritis
0.400
GeneticVariation
LHGDN
A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis.
12070782 2002
×
Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
Rheumatoid Arthritis
0.300
GeneticVariation
LHGDN
A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis.
11708406 2001
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Rheumatoid Arthritis
0.700
Biomarker
LHGDN
A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death.
16751383 2006
×
Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
Rheumatoid Arthritis
0.700
GeneticVariation
LHGDN
A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
15208781 2004
×
Entrez Id: 6354
Gene Symbol: CCL7
CCL7
Rheumatoid Arthritis
0.060
GeneticVariation
LHGDN
A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation.
16002730 2005
×
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
Rheumatoid Arthritis
0.100
AlteredExpression
LHGDN
A novel mechanism for the regulation of IFN-gamma inducible protein-10 expression in rheumatoid arthritis.
12718750 2003
×
Entrez Id: 142
Gene Symbol: PARP1
PARP1
Rheumatoid Arthritis
0.090
GeneticVariation
LHGDN
A poly(ADP-ribose) polymerase haplotype spanning the promoter region confers susceptibility to rheumatoid arthritis.
12632415 2003
TNFRSF1A
Rheumatoid Arthritis
0.100
GeneticVariation
LHGDN
A TNFR1 genotype with a protective role in familial rheumatoid arthritis.
14872483 2004
TNFRSF1B
Rheumatoid Arthritis
0.100
GeneticVariation
LHGDN
A TNFR1 genotype with a protective role in familial rheumatoid arthritis.
14872483 2004
HLA-DRB1
Rheumatoid Arthritis
0.500
Biomarker
LHGDN
Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope.
17075829 2006
×
Entrez Id: 4282
Gene Symbol: MIF
MIF
Rheumatoid Arthritis
0.400
AlteredExpression
LHGDN
Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor.
15170913 2004
×
Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14
Rheumatoid Arthritis
0.100
AlteredExpression
LHGDN
Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor.
15170913 2004