Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 Biomarker LHGDN Evidence of IL-18 as a novel angiogenic mediator. 11466388

2001

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.300 GeneticVariation LHGDN A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. 11708406

2001

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Anti-TNF therapy for rheumatoid arthritis and other inflammatory diseases. 11725485

2001

Entrez Id: 1513
Gene Symbol: CTSK
CTSK
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.070 AlteredExpression LHGDN Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. 11733367

2001

Entrez Id: 9507
Gene Symbol: ADAMTS4
ADAMTS4
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.050 AlteredExpression LHGDN Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. 11801682

2002

Entrez Id: 11096
Gene Symbol: ADAMTS5
ADAMTS5
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.030 AlteredExpression LHGDN Expression and regulation of aggrecanase in arthritis: the role of TGF-beta. 11801682

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 GeneticVariation LHGDN Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. 11838837

2002

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 GeneticVariation LHGDN Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes. 11838837

2002

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation LHGDN Rheumatoid arthritis association in Colombian population is restricted to HLA-DRB1*04 QRRAA alleles. 11857065

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Bone marrow progenitor cell reserve and function and stromal cell function are defective in rheumatoid arthritis: evidence for a tumor necrosis factor alpha-mediated effect. 11861275

2002

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.050 GeneticVariation LHGDN Evaluation of lipid profile, macular toxicity and clinical manifestations according to APO E genotype in systemic lupus erythematosus and rheumatoid arthritis patients treated with chloroquine. 11922198

2002

Entrez Id: 28461
Gene Symbol: IGHV1-69
IGHV1-69
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 GeneticVariation LHGDN Polymorphism in the immunoglobulin VH gene V1-69 affects susceptibility to rheumatoid arthritis in subjects lacking the HLA-DRB1 shared epitope. 11961170

2002

Entrez Id: 23765
Gene Symbol: IL17RA
IL17RA
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.060 AlteredExpression LHGDN Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. 11966773

2002

Entrez Id: 9051
Gene Symbol: PSTPIP1
PSTPIP1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.020 Biomarker LHGDN Mutations in CD2BP1 disrupt binding to PTP PEST and are responsible for PAPA syndrome, an autoinflammatory disorder. 11971877

2002

Entrez Id: 54
Gene Symbol: ACP5
ACP5
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.030 Biomarker LHGDN Serum tartrate-resistant acid phosphatase isoforms in rheumatoid arthritis. 11983200

2002

Entrez Id: 6891
Gene Symbol: TAP2
TAP2
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.200 GeneticVariation LHGDN TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France. 12047361

2002

Entrez Id: 6890
Gene Symbol: TAP1
TAP1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.040 GeneticVariation LHGDN TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France. 12047361

2002

Entrez Id: 3235
Gene Symbol: HOXD9
HOXD9
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.040 AlteredExpression LHGDN Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients. 12060849

2002

Entrez Id: 2212
Gene Symbol: FCGR2A
FCGR2A
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker LHGDN Immunoglobulin G fc-receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms related to disease severity in rheumatoid arthritis. 12064825

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 AlteredExpression LHGDN Regulation of TNF-alpha-mediated hyperplasia through TNF receptors, TRAFs, and NF-kappaB in synoviocytes obtained from patients with rheumatoid arthritis. 12067756

2002

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.470 GeneticVariation LHGDN RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response. 12070776

2002

Entrez Id: 4282
Gene Symbol: MIF
MIF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 GeneticVariation LHGDN A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. 12070782

2002

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.700 Biomarker LHGDN Anemia of chronic disease in rheumatoid arthritis is associated with increased apoptosis of bone marrow erythroid cells: improvement following anti-tumor necrosis factor-alpha antibody therapy. 12091338

2002

Entrez Id: 3181
Gene Symbol: HNRNPA2B1
HNRNPA2B1
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.210 AlteredExpression LHGDN Characterization of autoreactive T cells to the autoantigens heterogeneous nuclear ribonucleoprotein A2 (RA33) and filaggrin in patients with rheumatoid arthritis. 12097415

2002

Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.400 AlteredExpression LHGDN Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. 12105209

2002