×
Entrez Id: 22806
Gene Symbol: IKZF3
IKZF3
Lupus Erythematosus, Systemic
0.330
Biomarker
MGD
Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice.
12574333 2003
×
Entrez Id: 22806
Gene Symbol: IKZF3
IKZF3
Lupus Erythematosus, Systemic
0.330
Biomarker
MGD
Aiolos regulates B cell activation and maturation to effector state.
9806640 1998
×
Entrez Id: 4067
Gene Symbol: LYN
LYN
Lupus Erythematosus, Systemic
0.320
Biomarker
MGD
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
20512127 2010
×
Entrez Id: 4067
Gene Symbol: LYN
LYN
Lupus Erythematosus, Systemic
0.320
Biomarker
MGD
Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.
11672542 2001
×
Entrez Id: 6738
Gene Symbol: RO60
RO60
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
A lupus -like syndrome develops in mice lacking the Ro 60 -kDa protein, a major lupus autoantigen.
12788971 2003
×
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
×
Entrez Id: 959
Gene Symbol: CD40LG
CD40LG
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
TNFRSF13B
Lupus Erythematosus, Systemic
0.280
Biomarker
MGD
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.
12594954 2003
TNFRSF13B
Lupus Erythematosus, Systemic
0.280
Biomarker
MGD
Activation and accumulation of B cells in TACI-deficient mice.
11429549 2001
×
Entrez Id: 1536
Gene Symbol: CYBB
CYBB
Lupus Erythematosus, Systemic
0.260
Biomarker
MGD
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.
27096368 2016
×
Entrez Id: 3716
Gene Symbol: JAK1
JAK1
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
Taken together, Jak1 (S645P+/-) mice showed an increased activation of the IL-6-JAK-STAT pathway leading to a systemic lupus erythematosus -like phenotype and offering a new valuable tool to study the role of the JAK/STAT pathway in disease development.
23791841 2013
×
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
Visualizing the dynamics of p21(Waf1/Cip1) cyclin-dependent kinase inhibitor expression in living animals.
17848507 2007
×
Entrez Id: 6632
Gene Symbol: SNRPD1
SNRPD1
Lupus Erythematosus, Systemic
0.240
ModifyingMutation
RGD
The C-terminal peptide of amino acids 83-119 of the SmD1 protein is a target of the autoimmune response in human and murine lupus .
12571858 2003
×
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
11970874 2002
×
Entrez Id: 5788
Gene Symbol: PTPRC
PTPRC
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
11163182 2000
×
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
Genomic instability in Gadd45a-deficient mice.
10508513 1999
×
Entrez Id: 91937
Gene Symbol: TIMD4
TIMD4
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.
27096368 2016
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
×
Entrez Id: 3726
Gene Symbol: JUNB
JUNB
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
×
Entrez Id: 3930
Gene Symbol: LBR
LBR
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Because granulocytes isolated from human SLE patients had alterations in neutrophil nuclear morphology that resembled the Pelger-Huet anomaly, and had prominent mis-splicing of mRNA encoding the nuclear membrane protein lamin B receptor (LBR ), consistent with their Pelger-Huet-like nuclear morphology, we used a novel mouse model system to test the hypothesis that a disruption in the structure of the nucleus itself also contributes to the development of lupus autoimmunity.
27483354 2016
×
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis.
16170381 2005
×
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Gadd45a (-/-) mice develop an autoimmune disease, similar to human systemic lupus erythematosus (SLE ), characterized by high titers of anti-dsDNA, anti-ssDNA, and anti-histone autoantibodies, severe hematological disorders, autoimmune glomerulonephritis, and premature death.11970874 2002
×
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53.
12499274 2002
×
Entrez Id: 1647
Gene Symbol: GADD45A
GADD45A
Lupus Erythematosus, Systemic
0.220
Biomarker
MGD
Genomic instability in Gadd45a-deficient mice.
10508513 1999
×
Entrez Id: 122618
Gene Symbol: PLD4
PLD4
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
Pld4 mutant mice revealed autoimmune phenotypes suggesting functional involvement of PLD4 with the basics of SLE .30679154 2019