Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C4316903
Disease: Absence Seizures
Absence Seizures 		0.300 Biomarker CTD_human Inducible brain COX-2 facilitates the recurrence of hippocampal seizures in mouse rapid kindling. 14518562

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0333233
Disease: Active Hyperemia
Active Hyperemia 		0.300 Biomarker CTD_human Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut. 11820457

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents 		0.300 Biomarker CTD_human SO2 inhalation contributes to the development and progression of ischemic stroke in the brain. 20083630

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.600 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.600 Biomarker CTD_human In human samples, peak COX-2 expression occurred in PanIN2 lesions and remained moderately elevated in PanIN3 and adenocarcinoma tissues. 16820089

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.400 Biomarker CTD_human Aberrant arachidonic acid metabolism in esophageal adenocarcinogenesis, and the effects of sulindac, nordihydroguaiaretic acid, and alpha-difluoromethylornithine on tumorigenesis in a rat surgical model. 12507933

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. 16820089

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. 16820089

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Cyclooxygenase-2 expression in hamster and human pancreatic neoplasia. 16820089

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.400 Biomarker CTD_human Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. 17942926

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0750887
Disease: Adrenal Cancer
Adrenal Cancer 		0.300 Biomarker CTD_human Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo. 15492235

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001624
Disease: Adrenal Gland Neoplasms
Adrenal Gland Neoplasms 		0.300 Biomarker CTD_human Cyclooxygenase-2 is expressed in neuroblastoma, and nonsteroidal anti-inflammatory drugs induce apoptosis and inhibit tumor growth in vivo. 15492235

2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug 		0.300 Biomarker CTD_human Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice. 10698006

2000
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001925
Disease: Albuminuria
Albuminuria 		0.300 Biomarker CTD_human In summary, in transgenic mice with podocyte COX-2 overexpression, PAN increased albuminuria and induced foot process fusion. 17890881

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker CTD_human Effect of cyclooxygenase and nitric oxide synthase inhibitors on streptozotocin-induced hyperalgesia in rats. 17989504

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker CTD_human Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats. 17112505

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. 21414306

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. 14514642

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.360 Biomarker CTD_human We speculate that Cox-2 upregulation, through its pivotal role in inflammation, is instrumental in the ALS neurodegenerative process and that Cox-2 inhibition may be a valuable therapeutic avenue for the treatment of ALS. 11220737

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.360 Biomarker CTD_human These results suggest that cPLA2 plays an important role in supplying arachidonic acid to the COX-2 driven inflammatory pathway in ALS associated with SOD1 mutations. 15816863

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker CTD_human Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. 11220737

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0393554
Disease: Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis With Dementia 		0.300 Biomarker CTD_human Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. 15816863

2005