×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Adenocarcinoma
0.600
Biomarker
CTD_human
Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.
10485483
1999
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Adenocarcinoma
0.600
Biomarker
CTD_human
In human samples, peak COX-2 expression occurred in PanIN2 lesions and remained moderately elevated in PanIN3 and adenocarcinoma tissues.
16820089
2006
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Barrett Esophagus
0.600
Biomarker
CTD_human
Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors.
15387324
2004
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Barrett Esophagus
0.600
Biomarker
CTD_human
NO-releasing aspirin exerts stronger growth inhibitory effect on Barrett's adenocarcinoma cells than traditional aspirin.
17244951
2006
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Barrett Esophagus
0.600
Biomarker
CTD_human
Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells.
11059772
2000
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Renal Cell Carcinoma
0.600
Biomarker
CTD_human
Expression of cycloxygenase-2 in human bladder and renal cell carcinoma.
12664575
2002
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Colitis
0.600
Biomarker
CTD_human
TNBS-induced colitis was associated with enhanced COX-2 expression in the gut and increased circulating concentrations of PGE2 metabolite (PGEM).
11820457
2001
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
CTD_human
Western blots revealed overexpression of β-catenin, c-Myc, cyclin D1, inducible nitric oxide synthase and cyclooxygenase-2 in colon tumor samples.
21081470
2011
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
CTD_human
Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis.
12189188
2002
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Colonic Neoplasms
0.600
Biomarker
CTD_human
Cyclooxygenase-2 (COX-2 ) is overexpressed in colon tumors .
17667525
2007
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Depressive disorder
0.600
Biomarker
PSYGENET
Polymorphism -765 G/C in COX-2 -encoding gene promoter is associated with development of Alzheimer's disease, depression , carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis.
21655952
2012
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Depressive disorder
0.600
Biomarker
PSYGENET
Genetic variations in the COX2 and PLA2 genes increase the risk of IFN-alpha-induced depression , possibly by affecting the levels of EPA and DHA.
20034614
2010
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Depressive disorder
0.600
Biomarker
CTD_human
Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression .
19356723
2009
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Depressive disorder
0.600
Biomarker
PSYGENET
The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder.
22331023
2012
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Depressive disorder
0.600
Biomarker
PSYGENET
There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2 ) and Phospholipase2 (PLA2), in the aetiology of depression .
22580182
2013
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Depressive disorder
0.600
Biomarker
PSYGENET
Cyclooxygenase-2 (COX-2 ), the expression of which increases in depression , is an enzyme involved in inflammation and free radical processes.
20588070
2010
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Endometriosis
0.600
Biomarker
CTD_human
Higher expression of PLA2G2A, PTGS2 , AKR1B1, AKR1C3 and ABCC4 was seen in 22-B endometriosis cells compared to HIESC control cells.
25446850
2015
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Esophageal Neoplasms
0.600
Biomarker
CTD_human
We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer .
16322294
2005
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Esophageal Neoplasms
0.600
Biomarker
CTD_human
Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells.
11059772
2000
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Esophageal Neoplasms
0.600
Biomarker
CTD_human
Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms.
17707579
2007
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Hyperalgesia
0.600
Biomarker
CTD_human
The results of the study suggest participation of COX-1, COX-2 and iNOS, but not nNOS, in transmission of pain stimuli in STZ-induced diabetic hyperalgesia .
17989504
2008
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Hyperalgesia
0.600
Biomarker
CTD_human
These results indicate that intrathecal administration of COX-2 inhibitors has an anti-hyperalgesic effect on streptozotocin-induced mechanical hyperalgesia and we concluded that spinal COX-2 is pivotal in streptozotocin-induced hyperalgesia .
17112505
2007
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Hypertensive disease
0.600
Biomarker
CTD_human
Induction of hemeoxygenase-1 attenuates the hypertension and renal inflammation in spontaneously hypertensive rats.
20667508
2010
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Hypertensive disease
0.600
Therapeutic
CTD_human
Overexpression of HIF-1α transgene in the renal medulla attenuated salt sensitive hypertension in Dahl S rats.
22349312
2012
×
Entrez Id:
5743
Gene Symbol:
PTGS2
PTGS2
Hypertensive disease
0.600
Therapeutic
CTD_human
Our data also suggest a role for increased oxidative stress, which is at least in part dependent on enhanced COX-2 expression, in the mechanism(s) of enhanced aortic contractility in response to norepinephrine during DOCA-salt hypertension .
15834289
2005