Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.600 Biomarker CTD_human Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. 9024292

1997
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.400 Biomarker CTD_human We also observed a reduction of MSI phenotype after aspirin or sulindac treatment in a hMLH1-defective gastric cancer cell line SNU-1, which lacks COX-2 expression.Int.J.Cancer (Pred.Oncol.)84:400-403, 1999. 10404093

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker CTD_human Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. 10404093

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker CTD_human Overexpression of cyclooxygenase-2 protein is less frequent in gastric cancers with microsatellite instability. 10404093

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.600 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.400 Biomarker CTD_human The level of COX-2 mRNA was found to be elevated in carcinomas, relative to histologically normal pancreas from a healthy individual, as assessed by reverse transcription-PCR. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.400 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.400 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker CTD_human Our findings indicate that COX-2 up-regulation is a frequent event in pancreatic cancers and suggest that nonsteroidal anti-inflammatory drugs may be useful in the chemoprevention and therapy of pancreatic carcinoma. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.340 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205698
Disease: Undifferentiated carcinoma
Undifferentiated carcinoma 		0.310 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205643
Disease: Carcinoma, Cribriform
Carcinoma, Cribriform 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205644
Disease: Carcinoma, Granular Cell
Carcinoma, Granular Cell 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205696
Disease: Anaplastic carcinoma
Anaplastic carcinoma 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205697
Disease: Carcinoma, Spindle-Cell
Carcinoma, Spindle-Cell 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0205699
Disease: Carcinomatosis
Carcinomatosis 		0.300 Biomarker CTD_human Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. 10485483

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.400 Biomarker CTD_human These results indicate that COX-2 may play a role in bladder cancer in humans and support further study of COX-2 inhibitors as potential antitumor agents in human bladder cancer. 10582676

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.400 Biomarker CTD_human These results indicate that COX-2 may play a role in bladder cancer in humans and support further study of COX-2 inhibitors as potential antitumor agents in human bladder cancer. 10582676

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell 		0.350 Biomarker CTD_human COX-2 was not expressed in normal urinary bladder samples but was detected in 25 of 29 (86%) invasive transitional cell carcinomas of the urinary bladder and in 6 of 8 (75%) cases of carcinoma in situ. 10582676

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0878500
Disease: Intraepithelial Neoplasia
Intraepithelial Neoplasia 		0.350 Biomarker CTD_human Expression of cyclooxygenase-2 (COX-2) in human invasive transitional cell carcinoma (TCC) of the urinary bladder. 10582676

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker CTD_human Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach. 10588920

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038358
Disease: Gastric ulcer
Gastric ulcer 		0.600 Biomarker CTD_human Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions. 10594344

1999