Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0151526
Disease: Premature Birth
Premature Birth 		0.300 Biomarker CTD_human The mRNA expressions of COX-2 and TNF-α genes were 3.13 and 2.31 folds higher in PTB cases in comparison to term delivery. l0 inear positive correlations were observed between period of gestation (POG) and ΔCt of COX-2 and TNF-α genes. 27748297

2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0264423
Disease: Asthma, Occupational
Asthma, Occupational 		0.300 Biomarker CTD_human Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. 25721048

2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0151526
Disease: Premature Birth
Premature Birth 		0.300 Biomarker CTD_human Inflammatory-mediated pathway in association with organochlorine pesticides levels in the etiology of idiopathic preterm birth. 26055944

2015
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020295
Disease: Hydronephrosis
Hydronephrosis 		0.300 Biomarker CTD_human Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice. 22430074

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0040411
Disease: Tongue Neoplasms
Tongue Neoplasms 		0.300 Biomarker CTD_human Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model. 22561872

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0153349
Disease: Malignant neoplasm of tongue
Malignant neoplasm of tongue 		0.300 Biomarker CTD_human Early induction of cytokines/cytokine receptors and Cox2, and activation of NF-κB in 4-nitroquinoline 1-oxide-induced murine oral cancer model. 22561872

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker CTD_human A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a Chinese population. 22385256

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0002152
Disease: Alloxan Diabetes
Alloxan Diabetes 		0.300 Biomarker CTD_human Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. 21414306

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021367
Disease: Mammary Ductal Carcinoma
Mammary Ductal Carcinoma 		0.300 Biomarker CTD_human Methylation status and overexpression of COX-2 in Tunisian patients with ductal invasive breast carcinoma. 21153458

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0034013
Disease: Precocious Puberty
Precocious Puberty 		0.300 Biomarker CTD_human Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development. 21402727

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038433
Disease: Streptozotocin Diabetes
Streptozotocin Diabetes 		0.300 Biomarker CTD_human Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. 21414306

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0271527
Disease: Cryptogenic sexual precocity
Cryptogenic sexual precocity 		0.300 Biomarker CTD_human Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development. 21402727

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0342543
Disease: Central Precocious Puberty
Central Precocious Puberty 		0.300 Biomarker CTD_human Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development. 21402727

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1504412
Disease: Testotoxicosis
Testotoxicosis 		0.300 Biomarker CTD_human Manganese induces IGF-1 and cyclooxygenase-2 gene expressions in the basal hypothalamus during prepubertal female development. 21402727

2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0019064
Disease: Hemopericardium
Hemopericardium 		0.300 Biomarker CTD_human TCDD induced pericardial edema and relative COX-2 expression in medaka (Oryzias Latipes) embryos. 20801906

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0023212
Disease: Left-Sided Heart Failure
Left-Sided Heart Failure 		0.300 Biomarker CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0031039
Disease: Pericardial effusion
Pericardial effusion 		0.300 Biomarker CTD_human TCDD induced pericardial edema and relative COX-2 expression in medaka (Oryzias Latipes) embryos. 20801906

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0087086
Disease: Thrombus
Thrombus 		0.300 Biomarker CTD_human COX 2 inhibition induced a pro-thrombotic effect that was antagonized by aspirin at 1 mg/kg or 100 mg/kg. 20350286

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0235527
Disease: Heart Failure, Right-Sided
Heart Failure, Right-Sided 		0.300 Biomarker CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0242426
Disease: Chylopericardium
Chylopericardium 		0.300 Biomarker CTD_human TCDD induced pericardial edema and relative COX-2 expression in medaka (Oryzias Latipes) embryos. 20801906

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents 		0.300 Biomarker CTD_human SO2 inhalation contributes to the development and progression of ischemic stroke in the brain. 20083630

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1319853
Disease: Asthma, Aspirin-Induced
Asthma, Aspirin-Induced 		0.300 Biomarker CTD_human Genetic and ethnic risk factors associated with drug hypersensitivity. 20485159

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1563937
Disease: Atherogenesis
Atherogenesis 		0.300 Biomarker CTD_human Effects of paricalcitol and enalapril on atherosclerotic injury in mouse aortas. 20720404

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1959583
Disease: Myocardial Failure
Myocardial Failure 		0.300 Biomarker CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1961112
Disease: Heart Decompensation
Heart Decompensation 		0.300 Biomarker CTD_human MnSOD protects against COX1-mediated endothelial dysfunction in chronic heart failure. 20304815

2010