Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell 		0.350 Biomarker CTD_human COX-2 was not expressed in normal urinary bladder samples but was detected in 25 of 29 (86%) invasive transitional cell carcinomas of the urinary bladder and in 6 of 8 (75%) cases of carcinoma in situ. 10582676

1999
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0021846
Disease: Intestinal Polyps
Intestinal Polyps 		0.340 Biomarker CTD_human COX-2 is overexpressed in adenomas and colorectal cancers, and COX-2-specific inhibitors have been shown to inhibit intestinal polyps in Apc(Delta716) mice more effectively than dual COX-1/COX-2 inhibitors such as sulindac. 11507063

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.400 Biomarker CTD_human COX-2 mRNA expression was observed in the HT1197 bladder cancer cell line.JTE-522 was cytotoxic in HT1197 cells. 12442003

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.400 Biomarker CTD_human COX-2 mRNA expression was observed in the HT1197 bladder cancer cell line.JTE-522 was cytotoxic in HT1197 cells. 12442003

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.340 Biomarker CTD_human COX-2-derived prostanoids play a fundamental role in the development of Ang II-induced AAAs in both hyperlipidemic and nonhyperlipidemic mice. 16514081

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.340 Biomarker CTD_human COX-2 immunohistochemistry was performed in pancreata of hamsters subjected to the carcinogen N-nitrosobis-(2-oxopropyl)amine (BOP) and in human pancreatic tumors. 16820089

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker CTD_human COX-2 activity was significantly elevated in hamster and human pancreatic cancers compared to pair-matched normal pancreas. 16820089

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0020507
Disease: Hyperplasia
Hyperplasia 		0.310 Biomarker CTD_human Cyclooxygenase-2 (COX-2) causes hyperplasia in bladder cells and is considered a key biomarker in bladder cancer. 17093206

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0005684
Disease: Malignant neoplasm of urinary bladder
Malignant neoplasm of urinary bladder 		0.400 Biomarker CTD_human Cyclooxygenase-2 (COX-2) causes hyperplasia in bladder cells and is considered a key biomarker in bladder cancer. 17093206

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.400 Biomarker CTD_human Cyclooxygenase-2 (COX-2) causes hyperplasia in bladder cells and is considered a key biomarker in bladder cancer. 17093206

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0339143
Disease: Thyroid associated opthalmopathies
Thyroid associated opthalmopathies 		0.310 Biomarker CTD_human COX-2 and SCD, markers of inflammation and adipogenesis, are related to disease activity in Graves' ophthalmopathy. 17614770

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms 		0.600 Biomarker CTD_human Cyclooxygenase-2 (COX-2) is overexpressed in colon tumors. 17667525

2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.400 Biomarker CTD_human COX-2 mRNA expression is a frequent phenomenon in human ESCC tissue samples and plays an important role in the carcinogenesis of ESCC. 18197933

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker CTD_human COX-2 over-expression can up-regulate the expression of VEGF-C. VEGF-C might promote lymph node metastasis by a lymph-angiogenic pathway, then affect the prognosis of the patients with breast cancer. 18509974

2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0087086
Disease: Thrombus
Thrombus 		0.300 Biomarker CTD_human COX 2 inhibition induced a pro-thrombotic effect that was antagonized by aspirin at 1 mg/kg or 100 mg/kg. 20350286

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker PSYGENET Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker PSYGENET Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070

2010
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms 		0.400 Biomarker CTD_human A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a Chinese population. 22385256

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer 		0.300 Biomarker CTD_human A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a Chinese population. 22385256

2012
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.400 Biomarker CTD_human A large body of clinical, genetic, and biochemical evidence indicates that cyclooxygenase-2 (COX-2), a key enzyme for prostanoid biosynthesis, contributes to the promotion of colorectal cancer. 15753380

2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.320 Biomarker CTD_human A possible role of cyclooxygenase-2 (COX-2) in this process was emphasized by findings showing an impaired COX-2 expression in the nonpigmented ciliary epithelium (NPE) of patients with primary open-angle glaucoma. 16330497

2006
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Therapeutic CTD_human A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 11743745

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Therapeutic CTD_human A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 11743745

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Therapeutic CTD_human A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 11743745

2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Therapeutic CTD_human A protective role for cyclooxygenase-2 in drug-induced liver injury in mice. 11743745

2001