|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP), rs1344706, in the Zinc Finger Protein 804A (ZNF804A) gene, has been implicated in susceptibility to schizophrenia by several genome-wide association studies, follow-up association studies and meta-analyses.
|
21457757 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We verified that ZNF804A was significantly related to psychiatric diseases, and the association between ZNF804A rs1344706 and psychosis (schizophrenia and bipolar disorder) did not vary with disease or ethnicity.
|
25667193 |
2015 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
ZNF804A SNP rs1344706 confers genome-wide risk for schizophrenia and bipolar disorder.
|
23562677 |
2013 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
No differences in ZNF804A-immunoreactive neurons were seen in schizophrenia or related to rs1344706 (P > .05).
|
25162540 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The biological function of ZNF804A rs1344706, the first genome-wide supported risk variant of schizophrenia, remains largely unknown.
|
28078547 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Put in perspective, ZNF804A rs1344706, not only had a significant main effect, but its SZ-specific effects were two orders of magnitude more widespread than that of CACNA1C rs1006737.
|
27790829 |
2017 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Single-marker analysis revealed significant associations between 2 recently identified candidate schizophrenia susceptibility variants (rs1344706 and rs7597593) and a refined positive schizotypy phenotype characterized primarily by self-rated paranoia/ideas of reference.
|
23155182 |
2013 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this 2-stage study, we tested for an association between ZNF804A rs1344706 and cognitive functions known to be impaired in schizophrenia (IQ, episodic memory, working memory, and attention) in an Irish discovery sample.
|
20603450 |
2010 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia.
|
21349497 |
2011 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our result suggests that genetic variant rs1344706 might be associated with the development of schizophrenia in Asians.
|
28883732 |
2017 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that rs1344706 or a yet unknown polymorphism in linkage disequilibrium is also involved in conferring susceptibility to schizophrenia in samples with different (Asian) ancestral backgrounds.
|
23590871 |
2013 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The homozygous ZNF804A rs1344706 genotype (AA) conferred a high risk of sc</span>hizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC (F(2,165) = 13.43, P < 0.001).
|
29611035 |
2018 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs1344706 risk allele carriers of schizophrenia had increased gray matter in the brain regions including frontal lobe, temporal lobe, and other brain regions, but the carriers of healthy individuals had decreased gray matter and white matter integrity in the frontal lobe, central network, and other brain regions.
|
30962687 |
2019 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The common variant rs1344706 within the zinc-finger protein gene ZNF804A has been strongly implicated in schizophrenia (SZ) susceptibility by a series of recent genetic association studies.
|
24424391 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Though the two SNPs did not remain significant if we applied multiple corrections, our analysis should be interpreted as a primary replication study with in prior hypothesis, and rs1344706 and rs1366842 might confer a small but detectable risk of schizophrenia (and bipolar disorder) in Asians.
|
26866941 |
2016 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We tested the effect of rs1344706 genotype in 89 schizophrenia patients on 3 basic cognitive domains (working memory, processing speed and attention) shown to be severely impaired in schizophrenia.
|
22948380 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, the ZNF804A rs1344706 variant was not associated with schizophrenia in the Romanian population from Cluj Napoca (χ(2)=0.734, p=0.693).
|
22775511 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The current meta-analysis showed an association between rs1344706 and schizophrenia in Caucasian populations (P=0.028, OR=1.138, 95% CI: 1.014-1.278; P=0.004 for heterogeneity) and Asian populations (P=0.008, OR=1.092, 95% CI: 1.023-1.165; P=0.001 for heterogeneity), but not in other populations (P=0.286, OR=1.209, 95% CI: 0.853-1.714, P=0.120 for heterogeneity).
|
25526981 |
2014 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results did not support the association of rs1344706 with schizophrenia in Han Chinese, and further association studies with large samples from other ethnic backgrounds and focus on more SNPs of ZNF804A are warranted.
|
26934312 |
2016 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Taken together, the disconnectivity of the lHF-PCC tract seems to be a plausible intermediate phenotype that links rs1344706 and schizophrenia.
|
26654932 |
2016 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Patients homozygous for the ZNF804A risk allele for schizophrenia (rs1344706 AA) showed poorer improvement of positive symptoms (7.35 ± 0.46) compared to patients with a protective allele (9.41 ± 0.71, P = 0.022).
|
21892778 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Using this method, we were able to replicate an association between ZNF804A rs1344706 variant and schizophrenia in a Turkish population.
|
21988329 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The association of rs1344706 with WM changes in schizophrenia patients and healthy controls was analyzed using a full-factorial 2×2 analysis of variance.
|
21911029 |
2012 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
rs1344706
|
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although this data does not preclude the possibility of other functional variants in ZNF804A, it provides evidence that the rs1344706 SZ risk allele is the cis-regulatory variant directly responsible for this allelic expression imbalance in adult cortex.
|
24315717 |
2014 |