Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 26291
Gene Symbol: FGF21
FGF21 		0.010 Biomarker disease BEFREE In this study, we investigated whether fibroblast growth factor-21 (FGF21) was associated with metabolic effects and treatment response in depressed bipolar disorder patients. 29618013 2018
Entrez Id: 3560
Gene Symbol: IL2RB
IL2RB 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 56975
Gene Symbol: FAM20C
FAM20C 		0.010 Biomarker disease BEFREE These neurodegenerative disorders like Alzeimers, Parkinsons disease and neuropsychiatric disorders such as schizophrenia, bipolar, depression are caused due to the decline in physiological and psychological functions caused by ROS and RNS. 30644343 2018
Entrez Id: 1523
Gene Symbol: CUX1
CUX1 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 5027
Gene Symbol: P2RX7
P2RX7 		0.010 Biomarker disease BEFREE The activation of the ATP-gated P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7) produces microglial activation, a process which has been demonstrated in depression, bipolar disorder, and schizophrenia. 30664971 2019
Entrez Id: 5715
Gene Symbol: PSMD9
PSMD9 		0.010 GeneticVariation disease BEFREE PSMD9 is located in the chromosome 12q24 locus, which per se is in linkage with depression, bipolar disorder and anxiety. 24648162 2014
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 55729
Gene Symbol: ATF7IP
ATF7IP 		0.010 GeneticVariation disease BEFREE Studies reporting data on the clinimetric validity of the HAM-D6 and either the HAM-D17 or MADRS in non-psychotic unipolar or bipolar depression were included in the synthesis. 28490031 2017
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.010 Biomarker disease BEFREE Moreover, logistic regression analyses correctly classified BD and MDD patients with 98.1% accuracy, using a combination of IL-6, IL-8, ST2, sTNFR2 (directly associated with BD) and IL-12 and TNF-α (directly associated with MDD). 31693974 2020
Entrez Id: 9365
Gene Symbol: KL
KL 		0.010 Biomarker disease BEFREE Interleukin (IL)-1β, tumor necrosis factor (TNF)-α, soluble TNF receptor (sTNFR)1, IL-12 and IL-10 were significantly higher in MDD than in BD, whereas IL-6, sTNFR2, IL-18, IL-33, ST2 (IL1R Like 1) and KLOTHO were significantly higher in BD than in MDD. 31693974 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP 		0.010 Biomarker disease BEFREE C-reactive protein and response to lurasidone in patients with bipolar depression. 30102967 2018
Entrez Id: 8570
Gene Symbol: KHSRP
KHSRP 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 6929
Gene Symbol: TCF3
TCF3 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 2670
Gene Symbol: GFAP
GFAP 		0.010 AlteredExpression disease BEFREE Glial fibrillary acidic protein mRNA levels in the cingulate cortex of individuals with depression, bipolar disorder and schizophrenia. 15885920 2005
Entrez Id: 80114
Gene Symbol: BICC1
BICC1 		0.010 AlteredExpression disease BEFREE Serum BICC1 levels in drug-free patients with MDD (n=30), BM (n=30), and BD (n=13), and well-matched healthy controls (HC, n=30) were measured with ELISA kits. 30697050 2019
Entrez Id: 3554
Gene Symbol: IL1R1
IL1R1 		0.010 AlteredExpression disease BEFREE Interleukin (IL)-1β, tumor necrosis factor (TNF)-α, soluble TNF receptor (sTNFR)1, IL-12 and IL-10 were significantly higher in MDD than in BD, whereas IL-6, sTNFR2, IL-18, IL-33, ST2 (IL1R Like 1) and KLOTHO were significantly higher in BD than in MDD. 31693974 2020
Entrez Id: 27036
Gene Symbol: SIGLEC7
SIGLEC7 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 3586
Gene Symbol: IL10
IL10 		0.010 AlteredExpression disease BEFREE Interleukin (IL)-1β, tumor necrosis factor (TNF)-α, soluble TNF receptor (sTNFR)1, IL-12 and IL-10 were significantly higher in MDD than in BD, whereas IL-6, sTNFR2, IL-18, IL-33, ST2 (IL1R Like 1) and KLOTHO were significantly higher in BD than in MDD. 31693974 2020
Entrez Id: 11168
Gene Symbol: PSIP1
PSIP1 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.010 AlteredExpression disease BEFREE The studies support decreased PON1 activity as determined using phenylacetate (i.e., arylesterase or AREase) as a substrate, in depression, bipolar disorder, generalized anxiety disorder (GAD) and schizophrenia, especially in antipsychotic-free patients. 30592255 2019
Entrez Id: 4804
Gene Symbol: NGFR
NGFR 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 2022
Gene Symbol: ENG
ENG 		0.010 Biomarker disease BEFREE Further validation and investigation are required to illuminate the roles of B2RAN2 and ENG in MDD and BP. 28910601 2017
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181 		0.010 AlteredExpression disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 7133
Gene Symbol: TNFRSF1B
TNFRSF1B 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 7425
Gene Symbol: VGF
VGF 		0.010 AlteredExpression disease BEFREE Therefore, we aimed to investigate the relationship between serum VGF levels in BD and MDD patients. 30575991 2019