Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7226
Gene Symbol: TRPM2
TRPM2 		0.300 Biomarker disease CTD_human Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorder. 23602965 2013
Entrez Id: 8553
Gene Symbol: BHLHE40
BHLHE40 		0.300 Biomarker disease CTD_human Circadian polymorphisms in night owls, in bipolars, and in non-24-hour sleep cycles. 25395965 2014
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C 		0.310 Biomarker disease CTD_human Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
Entrez Id: 288
Gene Symbol: ANK3
ANK3 		0.300 Biomarker disease CTD_human Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
Entrez Id: 22854
Gene Symbol: NTNG1
NTNG1 		0.300 Biomarker disease CTD_human Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. 17507910 2008
Entrez Id: 84628
Gene Symbol: NTNG2
NTNG2 		0.300 Biomarker disease CTD_human Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. 17507910 2008
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B 		0.310 Biomarker disease CTD_human Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. 20357757 2010
Entrez Id: 2931
Gene Symbol: GSK3A
GSK3A 		0.300 Biomarker disease CTD_human Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. 20357757 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1 		0.310 Biomarker disease BEFREE Disrupted in Schizophrenia 1 (DISC1) is a key susceptibility gene implicated in major mental illnesses, such as schizophrenia, depression, bipolar disorder and autism, but the link between this protein and the pathology of these diseases remains unclear. 22291444 2012
Entrez Id: 85458
Gene Symbol: DIXDC1
DIXDC1 		0.300 Biomarker disease CTD_human DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling. 27752079 2018
Entrez Id: 1812
Gene Symbol: DRD1
DRD1 		0.300 Biomarker disease CTD_human Dopamine D1 receptor gene polymorphism is associated with prophylactic lithium response in bipolar disorder. 19153942 2009
Entrez Id: 6863
Gene Symbol: TAC1
TAC1 		0.300 Biomarker disease CTD_human Down-regulation of amygdala preprotachykinin A mRNA but not 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia. 15845098 2005
Entrez Id: 9575
Gene Symbol: CLOCK
CLOCK 		0.230 GeneticVariation disease BEFREE Effects of CLOCK gene variants and early stress on hopelessness and suicide in bipolar depression. 26204460 2015
Entrez Id: 776
Gene Symbol: CACNA1D
CACNA1D 		0.300 Biomarker disease CTD_human Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. 28194001 2017
Entrez Id: 2898
Gene Symbol: GRIK2
GRIK2 		0.300 Biomarker disease CTD_human Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. 18332879 2008
Entrez Id: 157
Gene Symbol: GRK3
GRK3 		0.300 Biomarker disease CTD_human Evidence that a single nucleotide polymorphism in the promoter of the G protein receptor kinase 3 gene is associated with bipolar disorder. 12808434 2003
Entrez Id: 4729
Gene Symbol: NDUFV2
NDUFV2 		0.300 Biomarker disease CTD_human Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. 19135101 2009
Entrez Id: 2022
Gene Symbol: ENG
ENG 		0.010 Biomarker disease BEFREE Further validation and investigation are required to illuminate the roles of B2RAN2 and ENG in MDD and BP. 28910601 2017
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.300 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005
Entrez Id: 2572
Gene Symbol: GAD2
GAD2 		0.300 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005
Entrez Id: 2571
Gene Symbol: GAD1
GAD1 		0.300 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005
Entrez Id: 2900
Gene Symbol: GRIK4
GRIK4 		0.300 Biomarker disease PSYGENET Genetic variants in the glutamate receptor gene GRIK4, which encodes the kainate receptor subunit GluK4, alter the susceptibility for depression, bipolar disorder and schizophrenia. 22203159 2012
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C 		0.310 GeneticVariation disease BEFREE Genetic variation in CACNA1C, which codes for the L-type calcium channel (LTCC) Ca<sub>v</sub> 1.2, is associated with clinical diagnoses of bipolar disorder, depression and schizophrenia. 28186690 2017
Entrez Id: 775
Gene Symbol: CACNA1C
CACNA1C 		0.310 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
Entrez Id: 5091
Gene Symbol: PC
PC 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019