Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE DJ-1 has been identified as a gene responsible for recessive familial Parkinson's disease (familial Parkinsonism), which is caused by a mutation in the PARK7 locus. 27270837 2017
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE Our aim was to examine the possibility of using DJ-1 (PARK7), as a novel therapeutic target for Parkinson's disease. 26024237 2016
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE One such protein is Parkinson protein 7, which has been implicated in Parkinson's disease, yet not associated with epilepsy, Alzheimers disease, or autism spectrum disorder. 26419955 2016
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). 25210784 2015
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease CTD_human Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese. 25149416 2015
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE Loss of DJ-1 protein stability and cytoprotective function by Parkinson's disease-associated proline-158 deletion. 23241025 2015
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE To date, MJFF has initiated and funded the generation of 30 different models, which include transgenic or knockout models of PD-relevant genes such as Park1 (also known as Park4 and SNCA), Park8 (LRRK2), Park7 (DJ-1), Park6 (PINK1), Park2 (Parkin), VPS35, EiF4G1 and GBA. 24046356 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease CTD_human DJ-1 was first identified as an activated ras-dependent oncogene and later found to be a causative gene for a familial form of Parkinson's disease, PARK7. 23037695 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. 23766857 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Mutations in DJ-1 (PARK7) leading to loss of functional protein cause familial PD and enhance sensitivity to oxidative insults. 23536331 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). 24899725 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7. 20087465 2014
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease CTD_human Loss-of-function mutations in the gene encoding the multifunctional protein, DJ-1, have been implicated in the pathogenesis of early-onset familial Parkinson's disease (PD), suggesting that DJ-1 may act as a neuroprotectant for dopaminergic (DA) neurons. 22898350 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) or parkinsonism. 23462481 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Data mining for single-nucleotide polymorphisms (SNP), reportedly associated with breast cancer in genome-wide association study (GWAS) that localize to chromosomes bearing known Parkinson's disease predisposition loci: PARK7, PINK1 (chromosome 1); SNCA (chromosome 4); PARK2 (chromosome 6); and LRRK2 (chromosome 12), was carried out. 23765085 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease RGD Pathogenic autosomal recessive mutations in the DJ-1 (Park7) or the PTEN-induced putative kinase 1 (Pink1 or PARK6) genes are associated with familial Parkinson's disease (PD). 24157858 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease CTD_human Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. 23792957 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE DJ-1/PARK7 has multiple functions as an antioxidant, an oncogene, and a molecular chaperone in vertebrates, and loss-of-function mutations in DJ-1 cause early onset of Parkinson's disease. 23026478 2013
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Loss-of-functional mutation in the DJ-1 gene causes a subset of familial Parkinson's disease. 22554508 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE 2-7) and intron boundaries of the DJ-1 gene were screened in 300 individuals (PD, 150; controls, 150) by direct sequencing. 21535932 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease CTD_human Early exposure to paraquat sensitizes dopaminergic neurons to subsequent silencing of PINK1 gene expression in mice. 22043175 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Loss of function mutations of Park7/DJ-1 gene increase the susceptibility of dopaminergic cells to reactive oxygen species and cause early onset familial Parkinson disease (PD). 21796667 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 Biomarker disease BEFREE Therefore, DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting α-synuclein expression. 22664331 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson's disease (PD). 22532838 2012
Entrez Id: 11315
Gene Symbol: PARK7
PARK7
0.800 GeneticVariation disease BEFREE DJ-1/PARK7 mutations have been linked with a familial form of early onset PD. 22173095 2012