Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8086
Gene Symbol: AAAS
AAAS
0.020 Biomarker phenotype BEFREE Recent studies have implicated the AAA+ ATPase pontin in many cellular activities that are highly relevant to carcinogenesis. 25751257 2016
Entrez Id: 8086
Gene Symbol: AAAS
AAAS
0.020 AlteredExpression phenotype BEFREE The evolutionarily conserved AAA ATPase ANCCA (AAA nuclear coregulator cancer-associated protein)/ATAD2 was identified as a direct target of oncogene AIB1/ACTR/SRC-3 and a transcriptional coregulator for estrogen and androgen receptors and is strongly implicated in tumorigenesis. 20855524 2010
Entrez Id: 284837
Gene Symbol: AATBC
AATBC
0.010 Biomarker phenotype BEFREE Moreover, mouse xenograft model revealed that knockdown of AATBC led to suppress tumorigenesis in vivo. 25473900 2015
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.010 Biomarker phenotype BEFREE O-linked glycans of secreted and membrane-bound proteins have an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation and tumorigenesis. 21625220 2012
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker phenotype BEFREE In combination with cell proliferative activities of c-myc and cyclin D1, MDR1 may initiate colorectal tumorigenesis by suppressing cell death pathways programmed in intestinal epithelial cells. 10987283 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker phenotype BEFREE In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/moderate dysplasia in carcinogenesis suggesting that these ABC transporters are involved in the early steps of carcinogenesis as previously reported for ABCB1. 25793771 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker phenotype BEFREE The multidrug resistance gene 1 (MDR1) seems to play a role in the carcinogenesis of colorectal tumors. 17146660 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression phenotype BEFREE Low ABCB1 gene expression is an early event in colorectal carcinogenesis. 23977225 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression phenotype BEFREE We conclude that P-gp is differentially expressed during oral tumorigenesis, and may be an indicator of the biological behavior of oral malignancies. 9036881 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 GeneticVariation phenotype BEFREE Thus, polymorphisms that reduce the activity of the MDR1 (ABCB1) efflux pump are potential risk factors for colorectal carcinogenesis. 17674045 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 AlteredExpression phenotype BEFREE A modulation of P-gp expression by p53 or other alterations during tumorigenesis have been reported. 10896996 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.080 Biomarker phenotype BEFREE BMP7 treatment induced senescence of GSC cultures and suppressed mRNA expression of CD133, MGMT, and ATP-binding cassette drug efflux transporters (ABCB1, ABCG2), as well as reconfigured transcriptional profiles in GSC by downregulating genes associated with EMT/migration/invasion, stemness, inflammation/immune response, and cell proliferation/tumorigenesis. 26546412 2016
Entrez Id: 8647
Gene Symbol: ABCB11
ABCB11
0.010 GeneticVariation phenotype BEFREE Although inherited ABCB11 mutations have previously been linked to HCC in a small number of cases, the molecular mechanisms of hepatocellular carcinogenesis in ABCB11 disease are unknown. 25016225 2015
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.010 Biomarker phenotype BEFREE In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/moderate dysplasia in carcinogenesis suggesting that these ABC transporters are involved in the early steps of carcinogenesis as previously reported for ABCB1. 25793771 2016
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.020 AlteredExpression phenotype BEFREE The results suggest that MRP expression is activated during the tumorigenesis of OSCCs and that this may play a role in de novo drug resistance in OSCCs. 11590075 2001
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.020 Biomarker phenotype BEFREE These results strongly suggest that MRP and gamma-GCS genes are coordinately up-regulated during colorectal carcinogenesis. 8705999 1996
Entrez Id: 85320
Gene Symbol: ABCC11
ABCC11
0.020 Biomarker phenotype BEFREE Recent reports disagree on whether ABCC11 is a risk factor for breast tumorigenesis, but its expression in breast cancer is poorly investigated. 23288347 2013
Entrez Id: 85320
Gene Symbol: ABCC11
ABCC11
0.020 GeneticVariation phenotype BEFREE Our data suggest that the c.538G>A variation in ABCC11 does not contribute to breast carcinogenesis in women of European descent. 21655989 2012
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
0.010 AlteredExpression phenotype BEFREE In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/moderate dysplasia in carcinogenesis suggesting that these ABC transporters are involved in the early steps of carcinogenesis as previously reported for ABCB1. 25793771 2016
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
0.010 AlteredExpression phenotype BEFREE Our data thus suggest that Wnt signaling represses ABCC3 expression during colon carcinogenesis, and that subsequent upregulation of ABCC3 expression during drug treatment might contribute to acquired drug resistance. 27709738 2017
Entrez Id: 215
Gene Symbol: ABCD1
ABCD1
0.010 Biomarker phenotype BEFREE The presentations were (1) First-pass metabolism of ethanol: Basic and clinical aspects, by Charles Lieber; (2) Intracellular CYP2E1 transport, oxidative stress, cytokine release, and ALD, by Magnus Ingelman-Sundberg; (3) Pulsatile ethanol metabolism in intragastric infusion models: Potential role in toxic outcomes, by Thomas M. Badger and Martin J.J. Ronis; (4) Free radicals, adducts, and autoantibodies resulting from ethanol metabolism: Role in ethanol-associated toxicity, by Emanuele Albano; and (5) Gastrointestinal metabolism of ethanol and its possible role in carcinogenesis, by Helmut Seitz. 12605083 2003
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.050 AlteredExpression phenotype BEFREE In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/moderate dysplasia in carcinogenesis suggesting that these ABC transporters are involved in the early steps of carcinogenesis as previously reported for ABCB1. 25793771 2016
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.050 AlteredExpression phenotype BEFREE FRAT1 and ABCG2 overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with PDAC. 26178481 2016
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.050 AlteredExpression phenotype BEFREE BMP7 treatment induced senescence of GSC cultures and suppressed mRNA expression of CD133, MGMT, and ATP-binding cassette drug efflux transporters (ABCB1, ABCG2), as well as reconfigured transcriptional profiles in GSC by downregulating genes associated with EMT/migration/invasion, stemness, inflammation/immune response, and cell proliferation/tumorigenesis. 26546412 2016
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.050 Biomarker phenotype BEFREE ABCG2, CD133 and CD117 are pivotal markers of cancer stem cell, which are involved in carcinogenesis and cancer progression. 26951883 2018