|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54).
|
28558900 |
2017 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor.
|
28549650 |
2017 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Rs449647 and rs405509 polymorphisms of <i>APOE</i> gene were not associated with an increase of risk of AD.
|
28900374 |
2017 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results demonstrate that the rs405509 T/T allele of APOE causes an age-related cognitive decline in non-demented elderly people, possibly by modulating brain network communication efficiency, which may be beneficial for understanding the neural mechanisms of rs405509-related cognitive aging and AD pathogenesis.
|
27636845 |
2017 |
|
rs63750264
|
|
T |
0.900 |
CausalMutation |
CLINVAR |
Clinical characterization of an APP mutation (V717I) in five Han Chinese families with early-onset Alzheimer's disease.
|
27838006 |
2017 |
|
rs63750264
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Alterations in endocytic protein expression with increasing age in the transgenic APP695 V717I London mouse model of amyloid pathology: implications for Alzheimer's disease.
|
28885485 |
2017 |
|
rs6656401
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.
|
26732597 |
2017 |
|
rs744373
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Bridging Integrator 1 Gene Polymorphism rs744373 and the Risk of Alzheimer's Disease in Caucasian and Asian Populations: An Updated Meta-Analysis.
|
26846281 |
2017 |
|
rs744373
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Mutants in rs1800587 of IL-1A, rs1143634 of IL-1B, rs12989701, and rs744373 of BIN1 were significantly associated with AD onset.
|
26768592 |
2017 |
|
rs744373
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT).
|
28316001 |
2017 |
|
rs75932628
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Shedding is not altered for the R47H-mutated TREM2 protein that confers an increased risk for the development of Alzheimers disease.
|
28923481 |
2017 |
|
rs11136000
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD.
|
26899953 |
2016 |
|
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Collectively, our analysis shows TOMM40 rs2075650 polymorphism is associated with AD susceptibility in Asian, Caucasian, and mixed populations.
|
27328316 |
2016 |
|
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Similarly, our evidence suggested that allele A of TOMM40 rs2075650 polymorphism was a risk factor for AD (OR=2.87, 95% CI: 2.46-3.34, P value <0.001).
|
26795201 |
2016 |
|
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Both methods' results showed two identical significant SNPs associated with the A β-42 levels in CSF (rs2075650 at intron region TOMM40 with p-value ≥ 1 × 10-16 and rs439401 in the intergenic region of LOC100129500 and APOC1 with p-value ≥ 1 × 10-9) and highlighted APOC1 and TOMM40, which are well-known genes previously associated with AD.
|
26576771 |
2016 |
|
rs2075650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We conclude that rs2075650 in TOMM40 gene may increase the risk of Alzheimer disease.
|
26572157 |
2016 |
|
rs2075650
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.
|
26993346 |
2016 |
|
rs2373115
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There was no significant association between SNPs of GAB2 rs2373115 (G > T) and PICALM rs541458 (C > T) and AD.
|
26611835 |
2016 |
|
rs3764650
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A comprehensive literature search for studies involving the association between gene polymorphisms and AD was performed, and we finally selected 3 genes (4 polymorphisms) for the meta-analysis: ABCA7 (rs3764650), CD33 (rs3865444), and TOMM40 (rs157580, rs2075650).
|
26795201 |
2016 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population".
|
26972434 |
2016 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The allele T of rs38</span>51179 in PICALM was associated with a 13 % increase in the risk of AD.
|
26611835 |
2016 |
|
rs3851179
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations.
|
25452228 |
2016 |
|
rs3865444
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Alleles A of CD33 rs3865444 and A of TOMM40 rs157580 were both protective factors for AD onset (OR=0.94, 95% CI: 0.90-0.98, P value=0.003; OR=0.62, 95% CI: 0.57-0.66, P value <0.001).
|
26795201 |
2016 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease.
|
27259692 |
2016 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD).
|
26825091 |
2016 |