|
rs755622
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A second MIF promoter polymorphism comprises a G-to-C single nucleotide polymorphism (SNP) at position -173 (rs755622), which is in strong linkage disequilibrium with -794 7-CATT and is associated with arthritis clinical severity and higher serum and synovial fluid MIF levels.
|
31745872 |
2020 |
|
rs755622
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism (SNP) -173 G/C (rs755622) on <i>MIF</i> gene has been associated with numerous diseases, such as arthritis and cancer.
|
29545822 |
2018 |
|
rs755622
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A significantly lower frequency of the G allele of rs755622 was observed in the oral aphthae, genital ulceration, hypopyon, and arthritis subgroups compared with controls (P(c) < 0.05).
|
22939113 |
2012 |
|
rs11614913
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings did not support the genetic association between miR-146a rs2910164 (G/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis.
|
31235484 |
2019 |
|
rs28940580
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Their parents were heterozygous for the same mutation p.M680I, however, the mother showed severe symptoms of FMF (recurrent attacks of fever, arthralgia and arthritis, abdominal pain, thoracic pain), the father showed recurrent pustulosis prevalent on the hands and limbs, with arthralgia and abdominal pain.
|
31443670 |
2019 |
|
rs2910164
|
|
|
0.020 |
GeneticVariation |
BEFREE |
But, we also find miRNA-146 rs2910164 and miRNA-499 rs3746444 polymorphism are associated with inflammatory arthritis in Middle East.
|
31223622 |
2019 |
|
rs2910164
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These findings did not support the genetic association between miR-146a rs2910164 (G/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis.
|
31235484 |
2019 |
|
rs204989
|
|
|
0.020 |
GeneticVariation |
BEFREE |
GPSM3 deficiency protects mice from inflammatory arthritis and, in humans, GPSM3 single-nucleotide polymorphisms (SNPs) are inversely associated with the risk of rheumatoid arthritis development; recently, these polymorphisms were linked to one particular SNP (rs204989) that decreases GPSM3 transcript abundance.
|
27307211 |
2016 |
|
rs204989
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Previous genome-wide association studies have highlighted single-nucleotide polymorphisms (SNPs; rs204989 and rs204991) in a region upstream of the GPSM3 transcription start site as being inversely correlated to the prevalence of rheumatoid arthritis (RA)-this association is supported by the protection afforded to Gpsm3-deficient mice in models of inflammatory arthritis.
|
26821282 |
2016 |
|
rs11614913
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A stratified analysis showed an association of the rs11614913 TT genotype and T allele with the arthritis subgroup of BD (P(c) = 5.3 × 10(-3), OR = 1.89; P(c) = 0.015, OR = 1.56, respectively).
|
23928854 |
2013 |
|
rs3743930
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Significant increase in abdominal pain and arthritis was found in patients with homozygote M694V mutation compared to those with E148Q mutation.
|
19777236 |
2010 |
|
rs3743930
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although four of the 26 patients with E148Q/E148Q were asymptomatic at the time of evaluation, abdominal pain was seen in 77% of the patients, fever in 66%, arthralgia in 50%, arthritis in 15.4%, and vomiting in 23.8%.
|
15458961 |
2005 |
|
rs28940580
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Arthritis frequency was found to be lower in the patients with homozygous Met680Ile mutation.
|
10662876 |
2000 |
|
rs11747270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD.
|
31654602 |
2020 |
|
rs4958847
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IRGM rs4958847 and rs11747270 increased the risk of developing arthritis in patients with CD.
|
31654602 |
2020 |
|
rs10036748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with psoriasis with TT genotype of rs10036748 in TNIP1, with lower BMI, without arthritis will achieve a better response to MTX.
|
31020648 |
2019 |
|
rs1544410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
rs1562444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Case-only analysis showed associations of rs2165667 and rs1562444 with arthritis, rs10830962 with malar rash, rs3760138 with immunological abnormality, and rs8150 with hematological abnormality.
|
31815152 |
2019 |
|
rs2165667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Case-only analysis showed associations of rs2165667 and rs1562444 with arthritis, rs10830962 with malar rash, rs3760138 with immunological abnormality, and rs8150 with hematological abnormality.
|
31815152 |
2019 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The clinical characteristics of BD patients were evaluated and patients with ocular lesions had a higher percentage of rs1544410 A alleles (p = 0.004), and patients with oral aphthous lesions, a positive pathergy tests, and arthritis had more rs2228570 C alleles than patients without these clinical findings (respectively, p < 0.001, p = 0.021, p = 0.045).
|
30730049 |
2019 |
|
rs224222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recurrent abdominal pain and arthritis/arthralgia were commonly observed in patients with M694V and R202Q mutations.
|
30284126 |
2019 |
|
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with rheumatoid arthritis (RA) or undifferentiated arthritis (UA) in the CONAART database (Argentine Consortium for Early Arthritis) were assessed for genetic risk factors for RA, specifically for HLA-DRB1 alleles and the PTPN22 rs2476601 polymorphism associated with progression to RA.This is a case-control study.
|
30306282 |
2019 |
|
rs3746444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study indicates that miRNA-499 rs3746444 polymorphism is associated with inflammatory arthritis susceptibility.
|
31223622 |
2019 |
|
rs731236
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs10735810, rs1544410, rs7975232, and rs731236 were associated with the onset of arthritis at both allelic and genotypic level (p < 0.01).
|
31011579 |
2019 |
|
rs741761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There were differences in the genotype frequencies and allele frequencies of rs741761 between SLE patients with and without arthritis.
|
31394943 |
2019 |