Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12936231
rs12936231
ZPBP2
0.720 GeneticVariation BEFREE For 3 of these SNPs, we found significant interaction with smoking and asthma (rs12936231, rs2290400, and rs8079416). 22626592

2012
dbSNP: rs12936231
rs12936231
ZPBP2
0.720 GeneticVariation BEFREE This study aimed to investigate whether variation in the functional 17q21 single nucleotide polymorphism rs12936231 affects the preventive potential of vitamin D against asthma.A combined secondary analysis of two randomised controlled trials of prenatal vitamin D supplementation for the prevention of asthma in offspring (Vitamin D Antenatal Asthma Reduction Trial (VDAART) and Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC<sub>2010</sub>)) was performed, stratifying by genotype and integrating metabolite data to explore underlying mechanisms.The protective effect of vitamin D on asthma/wheeze was evident among children with the low-risk rs12936231 GG genotype (hazard ratio (HR) 0.49, 95% CI 0.26-0.94, p=0.032) but not the high-risk CC genotype (HR 1.08, 95% CI 0.69-1.69, p=0.751). 31439681

2019
dbSNP: rs12936231
rs12936231
ZPBP2
0.720 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs11557467
rs11557467
ZPBP2
0.710 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010
dbSNP: rs11557467
rs11557467
ZPBP2
0.710 GeneticVariation BEFREE Subjects carrying the G allele of rs11557467 or the C allele of rs9303277 showed increased risk of asthma (odds ratio [OR] 1.27, 95% confidence interval 1.07-1.51, P = 0.006, and OR 1.27, 1.07-1.49, P = 0.005, respectively), even after adjusting for age and sex. 21985515

2011
dbSNP: rs4795397
rs4795397
ZPBP2
A 0.710 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies of asthma in Puerto Ricans. 28461288

2017
dbSNP: rs4795397
rs4795397
ZPBP2
0.710 GeneticVariation BEFREE We found that a single nucleotide polymorphism rs4795397 influences the activity of ZPBP2 promoter in vitro in an allele-dependent fashion, and also leads to nucleosome repositioning on the asthma-associated allele. 22271045

2012
dbSNP: rs1054609
rs1054609
ZPBP2
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs11078925
rs11078925
ZPBP2
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs11557466
rs11557466
ZPBP2
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs11655198
rs11655198
ZPBP2
0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965

2016
dbSNP: rs11870965
rs11870965
ZPBP2
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs12150079
rs12150079
ZPBP2
0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549

2011
dbSNP: rs12150079
rs12150079
ZPBP2
0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503

2010
dbSNP: rs10404342
rs10404342
ZNF71 ; ZNF71-SMIM17
0.010 GeneticVariation BEFREE This study found that several new genes might be associated with total IgE in asthmatics, such as CRIM1 (rs848512, P = 1.18×10(-6); rs711254, P = 6.73×10(-6)), ZNF71 (rs10404342, P = 7.60×10(-6)), TLN1 (rs4879926, P = 7.74×10(-6)), and SYNPO2 (rs1472066, P = 8.36×10(-6); rs1038770, P = 8.66×10(-6)). 23967269

2013
dbSNP: rs112502960
rs112502960
ZNF652 ; LOC102724596
A 0.700 GeneticVariation GWASCAT Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. 30552067

2019
dbSNP: rs12682865
rs12682865
ZNF618
0.700 GeneticVariation GWASDB Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. 23040885

2012
dbSNP: rs4979311
rs4979311
ZNF618
0.700 GeneticVariation GWASDB Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. 23040885

2012
dbSNP: rs2288884
rs2288884
ZNF614 ; LOC112268244
T 0.700 GeneticVariation GWASCAT Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. 24280104

2014
dbSNP: rs12460587
rs12460587
ZNF432 ; ZNF841
G 0.700 GeneticVariation GWASCAT Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. 24280104

2014
dbSNP: rs10995245
rs10995245
ZNF365 ; LOC105378327
A 0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738

2019
dbSNP: rs114357009
rs114357009
ZNF311
A 0.700 GeneticVariation GWASCAT Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. 31619474

2019
dbSNP: rs1250552
rs1250552
ZMIZ1
0.700 GeneticVariation GWASDB Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878

2011
dbSNP: rs1460239
rs1460239
ZFPM2
0.700 GeneticVariation GWASDB [Genome-wide association study of allergic diseases in Russians of Western Siberia]. 21790008

2011
dbSNP: rs12447718
rs12447718
ZFPM1
0.700 GeneticVariation GWASCAT Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts. 26025128

2015