rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma.
|
26125920 |
2015 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
There were no significant associations between SNP rs7216389 and asthma.
|
24735179 |
2014 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Asthma diagnosis was associated with rs11650680 and five other SNPs including rs7216389 (P = 0.019-0.034), whereas atopy was associated only with rs11650680 (P = 0.0004).
|
19175592 |
2009 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
rs7216389 was significantly associated with the development of wheeze (hazard ratio 1.64 [1.05-2.59], P value = 0.03), asthma (hazard ratio, 1.88 [1.15-3.07], P = 0.01), and acute severe exacerbations (hazard ratio 2.66 [1.58-4.48], P value = 0.0002).
|
19029000 |
2009 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Stronger effect sizes were observed between GWAS SNPs and gene expression in placentas than what has been reported in other tissues, such as the correlation between asthma risk allele, rs7216389-T and Gasdermin-B (GSDMB) in placenta (r2=27%) versus lung (r2=6%).
|
28854703 |
2017 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The diagnosis of asthma was associated with rs7216389 in ORMDL3 [odds ratio (OR) 0.74 and 95% confidence interval (95% CI) 0.56-0.99] and rs3756780 in ARG1 (OR 0.67, 95% CI 0.51-0.89) and BDR with rs2749935 in ARG1.
|
22472724 |
2012 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of this meta-analysis firmly established that genetic variation at the rs7216389 locus, which controls the expression of the ORMDL3, may be a major, independent predisposing factor for asthma in ethnically diverse populations.
|
25167772 |
2014 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A meta-analysis of five published studies on rs7216389 in nine populations gave an odds ratio for asthma of 1.44 (95% CI, 1.35-1.54, P < 0.00001).
|
19133921 |
2009 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking.
|
25331618 |
2015 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The haplotype (CAA) of rs7216389, rs4794820 and rs4065275 was associated with a lower risk of asthma susceptibility and a higher logPC(20).
|
22732088 |
2012 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between methylation and asthma was independent of the genotype in rs7216389, rs4065275 and rs12603332.
|
25256354 |
2015 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Thus, the contribution of rs7216389-T to the development of asthma is unlikely to operate only through an impact on the expression of ORMDL3 or GSDMB genes.
|
20372189 |
2010 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Cat and/or dog exposure from birth was associated with a lower prevalence of asthma among children with the rs7216389 high-risk TT genotype (adjusted hazard ratio, 0.16; 95% CI, 0.04-0.71; P = .015), with no effect in those with the CC/CT genotype (adjusted P = .283), demonstrating interaction between cat and dog exposure and the rs7216389 genotype (adjusted P = .044).
|
29102067 |
2018 |
rs7216389
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389).
|
21337730 |
2011 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Analyses of asthma phenotypes found no association with atopy or lung function, but rs2305480 and rs8066582 were associated with childhood asthma and rs9916279 was associated with asthma in smokers.
|
27163155 |
2016 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Eleven SNPs were significantly associated with asthma (P<0.01), of which three (rs8069176, rs2305480, and rs4795400) were strongly associated (P<0.001).
|
18923164 |
2008 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96).
|
26534891 |
2016 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Two coding variants (rs2305480 and rs11078928) of the gasdermin B (GSDMB) gene in the 17q21 locus were associated with lower asthma risk in both GERA (odds ratio, 0.92; P = 1.01 × 10<sup>-6</sup>) and EVE (odds ratio, 0.85; joint P<sub>EVE</sub> = 1.31 × 10<sup>-13</sup>).
|
29330013 |
2018 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
For two of these six loci (rs2305480 and rs8067378), there was evidence of association with asthma, and there was a weak association of asthma with rs8069176.
|
22370936 |
2012 |
rs2305480
|
|
|
0.860 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma.
|
23841068 |
2013 |
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96).
|
26534891 |
2016 |
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population.
|
29211635 |
2018 |
rs1295686
|
|
|
0.840 |
GeneticVariation |
BEFREE |
We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method.
|
26365633 |
2016 |