Source: ALL
Variant Gene Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE GMDR analyses revealed that rs7216389 in ORMDL3 and rs3756780 in ARG1 might interact for a risk of asthma. 22472724

2012

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE Asthma diagnosis was associated with rs11650680 and five other SNPs including rs7216389 (P = 0.019-0.034), whereas atopy was associated only with rs11650680 (P = 0.0004). 19175592

2009

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE The association between methylation and asthma was independent of the genotype in rs7216389, rs4065275 and rs12603332. 25256354

2015

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE A meta-analysis of five published studies on rs7216389 in nine populations gave an odds ratio for asthma of 1.44 (95% CI, 1.35-1.54, P < 0.00001). 19133921

2009

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389). 21337730

2011

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE The results of this meta-analysis firmly established that genetic variation at the rs7216389 locus, which controls the expression of the ORMDL3, may be a major, independent predisposing factor for asthma in ethnically diverse populations. 25167772

2015

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE Thus, the contribution of rs7216389-T to the development of asthma is unlikely to operate only through an impact on the expression of ORMDL3 or GSDMB genes. 20372189

2010

dbSNP: rs7216389
rs7216389
0.880 GeneticVariation BEFREE The haplotype (CAA) of rs7216389, rs4794820 and rs4065275 was associated with a lower risk of asthma susceptibility and a higher logPC(20). 22732088

2013

dbSNP: rs1295686
rs1295686
0.820 GeneticVariation BEFREE We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. 26365633

2016

dbSNP: rs1295686
rs1295686
0.820 GeneticVariation BEFREE There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. 23841068

2013

dbSNP: rs1837253
rs1837253
0.820 GeneticVariation BEFREE Surprisingly, rs1837253 (consistently associated with asthma) showed no correlation with TSLP expression levels. 26119467

2016

dbSNP: rs1837253
rs1837253
0.820 GeneticVariation BEFREE In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 × 10(-6) ). 20560908

2011

dbSNP: rs2244012
rs2244012
0.820 GeneticVariation BEFREE Multiple SNPs in the RAD50-IL13 region on chromosome 5q31.1 were associated with asthma: rs2244012 in intron 2 of RAD50 (P = 3.04E-07). 20159242

2010

dbSNP: rs2244012
rs2244012
0.820 GeneticVariation BEFREE We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. 26365633

2016

dbSNP: rs2305480
rs2305480
0.820 GeneticVariation BEFREE A 17q12 variant, rs2305480, was associated with asthma-like symptoms in preschool children, and this association was modified by smoke exposure already during fetal life, and in infancy. 22469062

2012

dbSNP: rs2305480
rs2305480
0.820 GeneticVariation BEFREE GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic). 24066901

2014

dbSNP: rs4129267
rs4129267
0.820 GeneticVariation BEFREE Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP). 21907864

2011

dbSNP: rs4129267
rs4129267
0.820 GeneticVariation BEFREE The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with respect to asthma severity. 22554704

2012

dbSNP: rs10197862
rs10197862
0.810 GeneticVariation BEFREE However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878

2011

dbSNP: rs11071559
rs11071559
0.810 GeneticVariation BEFREE To investigate the impact of RORA on asthma susceptibility, we performed a genetic association study between RORA single nucleotide polymorphisms (SNPs) in the vicinity of the asthma-associated SNP (rs11071559) and asthma-related traits. 23565190

2013

dbSNP: rs11078927
rs11078927
0.810 GeneticVariation BEFREE GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic). 24066901

2014

dbSNP: rs13408661
rs13408661
0.810 GeneticVariation BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483

2013

dbSNP: rs1342326
rs1342326
0.810 GeneticVariation BEFREE We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)). 20860503

2010

dbSNP: rs2284033
rs2284033
0.810 GeneticVariation BEFREE We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)). 20860503

2010

dbSNP: rs2290400
rs2290400
0.810 GeneticVariation BEFREE For 3 of these SNPs, we found significant interaction with smoking and asthma (rs12936231, rs2290400, and rs8079416). 22626592

2012