Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE rs7216389 was significantly associated with the development of wheeze (hazard ratio 1.64 [1.05-2.59], P value = 0.03), asthma (hazard ratio, 1.88 [1.15-3.07], P = 0.01), and acute severe exacerbations (hazard ratio 2.66 [1.58-4.48], P value = 0.0002). 19029000

2009

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE A meta-analysis of five published studies on rs7216389 in nine populations gave an odds ratio for asthma of 1.44 (95% CI, 1.35-1.54, P < 0.00001). 19133921

2009

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE Asthma diagnosis was associated with rs11650680 and five other SNPs including rs7216389 (P = 0.019-0.034), whereas atopy was associated only with rs11650680 (P = 0.0004). 19175592

2009

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE Thus, the contribution of rs7216389-T to the development of asthma is unlikely to operate only through an impact on the expression of ORMDL3 or GSDMB genes. 20372189

2010

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389). 21337730

2011

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE The diagnosis of asthma was associated with rs7216389 in ORMDL3 [odds ratio (OR) 0.74 and 95% confidence interval (95% CI) 0.56-0.99] and rs3756780 in ARG1 (OR 0.67, 95% CI 0.51-0.89) and BDR with rs2749935 in ARG1. 22472724

2012

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE The haplotype (CAA) of rs7216389, rs4794820 and rs4065275 was associated with a lower risk of asthma susceptibility and a higher logPC(20). 22732088

2012

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE There were no significant associations between SNP rs7216389 and asthma. 24735179

2014

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE The results of this meta-analysis firmly established that genetic variation at the rs7216389 locus, which controls the expression of the ORMDL3, may be a major, independent predisposing factor for asthma in ethnically diverse populations. 25167772

2014

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE The association between methylation and asthma was independent of the genotype in rs7216389, rs4065275 and rs12603332. 25256354

2015

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking. 25331618

2015

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE This meta-analysis indicates that ORMDL3 rs7216389 may contribute to increasing susceptibility to asthma. 26125920

2015

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE Stronger effect sizes were observed between GWAS SNPs and gene expression in placentas than what has been reported in other tissues, such as the correlation between asthma risk allele, rs7216389-T and Gasdermin-B (GSDMB) in placenta (r2=27%) versus lung (r2=6%). 28854703

2017

dbSNP: rs7216389
rs7216389
0.900 GeneticVariation BEFREE Cat and/or dog exposure from birth was associated with a lower prevalence of asthma among children with the rs7216389 high-risk TT genotype (adjusted hazard ratio, 0.16; 95% CI, 0.04-0.71; P = .015), with no effect in those with the CC/CT genotype (adjusted P = .283), demonstrating interaction between cat and dog exposure and the rs7216389 genotype (adjusted P = .044). 29102067

2018

dbSNP: rs2305480
rs2305480
0.860 GeneticVariation BEFREE Eleven SNPs were significantly associated with asthma (P<0.01), of which three (rs8069176, rs2305480, and rs4795400) were strongly associated (P<0.001). 18923164

2008

dbSNP: rs2305480
rs2305480
0.860 GeneticVariation BEFREE For two of these six loci (rs2305480 and rs8067378), there was evidence of association with asthma, and there was a weak association of asthma with rs8069176. 22370936

2012

dbSNP: rs2305480
rs2305480
0.860 GeneticVariation BEFREE GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic). 24066901

2013

dbSNP: rs2305480
rs2305480
0.860 GeneticVariation BEFREE IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96). 26534891

2016

dbSNP: rs2305480
rs2305480
0.860 GeneticVariation BEFREE Analyses of asthma phenotypes found no association with atopy or lung function, but rs2305480 and rs8066582 were associated with childhood asthma and rs9916279 was associated with asthma in smokers. 27163155

2016

dbSNP: rs2305480
rs2305480
0.860 GeneticVariation BEFREE Two coding variants (rs2305480 and rs11078928) of the gasdermin B (GSDMB) gene in the 17q21 locus were associated with lower asthma risk in both GERA (odds ratio, 0.92; P = 1.01 × 10<sup>-6</sup>) and EVE (odds ratio, 0.85; joint P<sub>EVE</sub> = 1.31 × 10<sup>-13</sup>). 29330013

2018

dbSNP: rs1295686
rs1295686
0.840 GeneticVariation BEFREE There are controversies on the association between interleukin-13 (IL-13) +1923C/T polymorphism (rs1295686) and the risk of asthma. 23841068

2013

dbSNP: rs1295686
rs1295686
0.840 GeneticVariation BEFREE We conducted an association study by genotyping four SNPs (rs2244012 and rs6871536 in RAD50 as well as rs1295686 and rs1800925 in IL13) in 652 asthmatic children and age-matched 752 healthy controls from Northeastern Han Chinese to evaluate the asthma susceptibility with each individual SNP using SNaPshot genotyping method. 26365633

2016

dbSNP: rs1295686
rs1295686
0.840 GeneticVariation BEFREE IL13_rs1295686 was associated with all asthma (OR 1.64, 95% CI 1.16-2.32) and early-onset asthma (OR 1.92, 95% CI 1.20-3.06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0.69, 95% CI 0.49-0.96). 26534891

2016

dbSNP: rs1295686
rs1295686
0.840 GeneticVariation BEFREE IL-13 minor T and A alleles for rs1295686 and rs20541, respectively, were associated with significantly higher risk of asthma in the Saudi Arabian population. 29211635

2018

dbSNP: rs1342326
rs1342326
0.840 GeneticVariation BEFREE We observed associations of genomewide significance between asthma and the following single-nucleotide polymorphisms: rs3771166 on chromosome 2, implicating IL1RL1/IL18R1 (P=3×10(−9)); rs9273349 on chromosome 6, implicating HLA-DQ (P=7×10(−14)); rs1342326 on chromosome 9, flanking IL33 (P=9×10(−10)); rs744910 on chromosome 15 in SMAD3 (P=4×10(−9)); and rs2284033 on chromosome 22 in IL2RB (P=1.1×10(−8)). 20860503

2010