|
rs2290400
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Haplotypes at 17q12-q21 encompassing rs2290400 are known to determine the susceptibility of early-onset asthma by affecting the expression of flanking genes.
|
27352912 |
2016 |
|
rs2290400
|
|
C |
0.820 |
GeneticVariation |
GWASCAT |
Combining genomewide association study and lung eQTL analysis provides evidence for novel genes associated with asthma.
|
27439200 |
2016 |
|
rs3859192
|
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
|
rs3859192
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The present study reports that the polymorphic genomic variant rs3816470 is significantly and independently associated with asthma in the studied population, while the variants, rs6503525 and rs3859192, also indicate a significant association with asthma in this population when family history of the disease is taken as a covariate.
|
26203825 |
2015 |
|
rs7212938
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In LD block1 (93 kb) consisting of six SNPs (rs12936231, rs7216389, rs7216558, rs9894164, rs1007654 and rs7212938), none of the haplotypes show any significant association with asthma except the haplotype "CCTCAG", which is a significant protective factor against asthma having frequency 0.051 in controls while 0.017 in cases (p = 3.56 × 10(-2), χ2 = 4.415).
|
26203825 |
2015 |
|
rs11078927
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
|
24406073 |
2014 |
|
rs7212938
|
|
G |
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
|
rs11071559
|
|
|
0.820 |
GeneticVariation |
BEFREE |
To investigate the impact of RORA on asthma susceptibility, we performed a genetic association study between RORA single nucleotide polymorphisms (SNPs) in the vicinity of the asthma-associated SNP (rs11071559) and asthma-related traits.
|
23565190 |
2013 |
|
rs11078927
|
|
|
0.820 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
|
rs7927894
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Subgroup analysis revealed no significant association of rs7927894 with early age of onset of the disease, concomitant asthma and allergic rhinoconjunctivitis, total serum IgE levels and family history of atopy.
|
23557745 |
2013 |
|
rs11071559
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
rs2290400
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Sixteen SNPs were significantly associated with asthma after multiple testing correction (P ≤ .01), of which 5 (rs2290400, rs8079416, rs3894194, rs7212938, and rs3859192) were strongly associated (FDR P ≤ .0002), and one was novel (IKZF3-rs1453559).
|
22626592 |
2012 |
|
rs3771180
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
|
rs3859192
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We observed significant interaction between 5 SNPs and smoking on AHR, and 3 interacted with smoking in relation to asthma with AHR (rs4795404, rs4795408, rs3859192</span>).
|
22626592 |
2012 |
|
rs4129267
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The IL6R single nucleotide polymorphism (SNP) rs4129267 has recently been identified as an asthma susceptibility locus in subjects of European ancestry but has not been characterized with respect to asthma severity.
|
22554704 |
2012 |
|
rs11071559
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
rs11078927
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs11078927
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs2290400
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs3771180
|
|
|
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs3771180
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs4129267
|
|
T |
0.820 |
GeneticVariation |
GWASDB |
Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
|
21907864 |
2011 |
|
rs4129267
|
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
|
21907864 |
2011 |
|
rs4129267
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Two loci were confirmed to associate with asthma risk in the replication cohorts and reached genome-wide significance in the combined analysis of all available studies (n=57,800): rs4129267 (OR 1·09, combined p=2·4×10(-8)) in the interleukin-6 receptor (IL6R) gene and rs7130588 (OR 1·09, p=1·8×10(-8)) on chromosome 11q13.5 near the leucine-rich repeat containing 32 gene (LRRC32, also known as GARP).
|
21907864 |
2011 |
|
rs7212938
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Asthma susceptibility was associated with GG of the GSDMA (rs7212938) and TT of GSDMB (rs7216389).
|
21337730 |
2011 |