|
rs1045242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs1045242 in the TNFAIP8 gene was strongly associated with with EC risk (adjust OR: 1.636, 95% CI 1.107-2.417, P = 0.014). rs11064 SNPs correlated with TNFAIP8 protein expression in EC (P = 0.015).
|
31043860 |
2019 |
|
rs11064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs11064 in TNFAIP8 increased EC risk and significantly related with its protein expression in northern Chinese women.
|
31043860 |
2019 |
|
rs1524107
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs2066992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs2072472
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analysis by age showed that rs2072472 was associated with endometrial cancer risk in age >54 subgroup.
|
30895748 |
2019 |
|
rs3218896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk.
|
30895748 |
2019 |
|
rs3742330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Dicer rs3742330 AG and GG genotypes may have the potential to be used as a predictor of poor prognosis in the management of EC case.
|
30488844 |
2019 |
|
rs4851527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk.
|
30895748 |
2019 |
|
rs587781462
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To the best of our knowledge, this is the first description of MSH6 T767I pathogenic variant that could be associated with a hereditary endometrial cancer.
|
31100584 |
2019 |
|
rs786205228
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Restoration of wild-type PPP2R1A in P179R</span>-mutant endometrial cancer cells increases phosphatase activity and inhibits tumor growth <i>in vivo</i> Furthermore, a small-molecule activator of PP2A (SMAP) phenocopies restoration of wild-type PPP2R1A to suppress tumor growth.
|
31416848 |
2019 |
|
rs9261204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor allele of rs9261204 was significantly associated with increased risk of EC (OR: 1.33; 95% CI: 1.09-1.61; p = 0.004).
|
31599404 |
2019 |
|
rs1156807933
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MAX Mutations in Endometrial Cancer: Clinicopathologic Associations and Recurrent MAX p.His28Arg Functional Characterization.
|
29155953 |
2018 |
|
rs117039649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Increasing evidence has suggested that rs2279744 is associated with rs117039649 polymorphism, which can increase the risk of gynecological cancers, including cervical, ovarian, breast, and endometrial cancer.
|
29480845 |
2018 |
|
rs2475335
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cross-disease GWAS meta-analysis highlighted 13 distinct loci associated at P ≤ 10<sup>-5</sup> with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10<sup>-8</sup> , OR = 1.11, 95% CI = 1.07-1.15).
|
29608257 |
2018 |
|
rs3761548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the frequency of the A allele in rs3761548 in patients with EC was significantly lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC genotype showed a significant protective effect on EC in codominant, dominant, and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), and AA genotype was more frequent in patients with cervical invasion (recessive model: OR 3.55, 95% CI: 1.10-11.44, P = .046).
|
29718856 |
2018 |
|
rs4980524
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The promoter reporter with rs4980524 GG genotype significantly increased luciferase activity than that with TT genotype in endometrial cancer RL95-2 cells, and the primary endometrial stromal cells carrying rs4980524 GG genotype expressed higher protein levels of STIP1 and MMP9 than those carrying the TT one.
|
29673672 |
2018 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PON1 Q192R polymorphism is not associated with the risk of endometrial cancer.
|
30178714 |
2018 |
|
rs12112075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Single Nucleotide Polymorphism -2548 G/A (rs12112075) of leptin gene with endometrial cancer and uterine leiomyomas.
|
28964972 |
2017 |
|
rs371077728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a <i>BRCA-</i>negative family with positive history of breast and endometrial cancer, next-generation sequencing-based panel testing identified a mutation in the <i>MRE11A</i> gene (NM_005590 c.1090C>T: p.Arg364Ter).
|
28559769 |
2017 |
|
rs1042838
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings provide empirical evidence that PGR rs1042838 and rs10895068 polymorphisms may be involved in the pathogenesis of endometrial cancer.
|
26881523 |
2016 |
|
rs10512263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Classification and regression tree (CART) demonstrated that women carrying both the genotypes of TGFBR1 rs6478974 TT and rs10512263 TC/CC had the highest risk of EC (aOR = 7.86, 95% CI = 3.42-18.07, P<0.0001).
|
27171242 |
2016 |
|
rs10733710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression (LR) showed that the genetic variants of TGFB1 rs1800469, TGFBR1 rs6478974 and rs10733710, TWIST1 rs4721745 were associated with decreased EC risk, and these four loci showed a dose-dependent effect (Ptrend < 0.0001).
|
27171242 |
2016 |
|
rs10895068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings provide empirical evidence that PGR rs1042838 and rs10895068 polymorphisms may be involved in the pathogenesis of endometrial cancer.
|
26881523 |
2016 |
|
rs1501299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ may be considered to be a risk factor of endometrial cancer.
|
26386690 |
2016 |
|
rs1740828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe one new locus reaching genome-wide significance (P < 5 × 10 <sup>-</sup><sup>8</sup>) at 6p22.3 (rs1740828; P = 2.29 × 10 <sup>-</sup><sup>8</sup>, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
|
27008869 |
2016 |