|
rs12970291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Another polymorphism, rs12970291 near gene TSHZ1, was associated with both CRC and EC (OR = 1.26, P = 4.82 × 10(-8)), with the alleles showing opposite effects on the risks of the two cancers.
|
26621817 |
2015 |
|
rs1740828
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We describe one new locus reaching genome-wide significance (P < 5 × 10 <sup>-</sup><sup>8</sup>) at 6p22.3 (rs1740828; P = 2.29 × 10 <sup>-</sup><sup>8</sup>, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.
|
27008869 |
2016 |
|
rs17782313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MC4R rs17782313 polymorphism was not related to endometrial cancer risk (per allele OR = 0.98; 95% CI: 0.91-1.06; p = 0.68).
|
21347432 |
2011 |
|
rs2046210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggests that rs2046210 may play a role in the etiology of endometrial cancer.
|
21272446 |
2011 |
|
rs605965
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The 870 G>A polymorphisms (rs605965) in the cyclin D1 gene was genotyped in an Australian endometrial cancer case-control population including 191 cases and 291 controls using real-time PCR analysis.
|
18822177 |
2008 |
|
rs7679673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs7679673, ~6.3kb upstream of TET2 and previously reported to be associated with prostate cancer risk, was associated with endometrial cancer risk in the direction opposite to that for prostate cancer [meta-analysis odds ratio = 0.87 (per copy of the C allele), 95% confidence interval = 0.81, 0.93; P = 7.37×10(-5)] with no evidence of heterogeneity across studies (P heterogeneity = 0.66).
|
24832084 |
2014 |
|
rs889312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also observed a nonsignificant inverse association with rs889312 (MAP3K1) variant carriers [OR = 0.85 (95% CI: 0.68-1.05)] and rs1219648 (FGFR2) variant carriers [OR= 0.86 (95% CI: 0.69-1.06) and endometrial cancer risk.
|
18785201 |
2008 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our observation suggests that MDR1 C3435T polymorphism is correlated with endometrial cancer susceptibility.
|
17300681 |
2007 |
|
rs1063539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed an epistatic interaction between survivin rs9904341 CC+CG genotype and ADIPOQ rs1063539 GG genotype increasing the risk of EC compared to those with other genotypes [OR: 4.86(1.88-12.54), P=0.001].
|
25613698 |
2015 |
|
rs1501299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ may be considered to be a risk factor of endometrial cancer.
|
26386690 |
2016 |
|
rs4994
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The prevalence of the Arg allele of the Trp64Arg polymorphism in the beta3-adrenergic receptor gene may contribute to the susceptibility to endometrial cancer among obese/overweight individuals.
|
15743038 |
2004 |
|
rs1200003171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings show for the first time that elevated expression of p53-R175H mutant may exert gain-of-function activity to activate the EGFR/PI3K/AKT pathway and thus may contribute to the invasive phenotype in endometrial cancer.
|
19917135 |
2009 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analysed the presence of the AKT1 (E17K) mutation in 89 endometrial cancer tissue specimens and in 12 endometrial cancer cell lines by PCR and direct sequencing.
|
19491896 |
2009 |
|
rs2494737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest YY1 is a positive regulator of AKT1, mediating the stimulatory effects of rs2494737 increasing endometrial cancer risk.
|
27259051 |
2016 |
|
rs2494750
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs (rs72715985), (rs2494750), and (rs74090038) of Akt1 gene are not associated with endometrial cancer in Iranian subjects.
|
26296520 |
2015 |
|
rs72715985
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs (rs72715985), (rs2494750), and (rs74090038) of Akt1 gene are not associated with endometrial cancer in Iranian subjects.
|
26296520 |
2015 |
|
rs74090038
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs (rs72715985), (rs2494750), and (rs74090038) of Akt1 gene are not associated with endometrial cancer in Iranian subjects.
|
26296520 |
2015 |
|
rs2498801
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the AKT1 rs2498801 genotype significantly increased risk of endometrial cancer (adjusted OR, 1.94; 95% CI, 1.02-3.67 in a recessive model).
|
22146979 |
2012 |
|
rs892119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
(2) In Cox regression analyses, three SNPs (PIK3R1 rs1862162, AKT2 rs892119, and PIK3CA rs2699887) showed significant associations with survival of endometrial cancer patients.
|
22146979 |
2012 |
|
rs1204038
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles in three correlated htSNPs (rs6152, rs1204038, and rs1337082; r(2) >0.6) were associated with increased risk for endometrial cancer.
|
19190146 |
2009 |
|
rs6152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Minor alleles in three correlated htSNPs (rs6152, rs1204038, and rs1337082; r(2) >0.6) were associated with increased risk for endometrial cancer.
|
19190146 |
2009 |
|
rs4987886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated an increased risk of developing endometroid endometrial cancer for homozygous carriers of the rare allele (AA) of a tagSNP (rs4987886) in CHEK2 (P = 0.005) when contrasted with GG carriers.
|
17164260 |
2007 |
|
rs3184504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A combined analysis revealed one genome-wide significant polymorphism, rs3184504, on chromosome 12q24 (OR = 1.10, P = 7.23 × 10(-9)) with shared effects on CRC and EC risk.
|
26621817 |
2015 |
|
rs3768235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A polymorphism in exon 3 (638G-->A) was seen in 4/42 (9.5%) MSI-positive endometrial cancers and 0/5 MSI-positive endometrial cancer cell lines.
|
11180594 |
2001 |
|
rs9904341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed an epistatic interaction between survivin rs9904341 CC+CG genotype and ADIPOQ rs1063539 GG genotype increasing the risk of EC compared to those with other genotypes [OR: 4.86(1.88-12.54), P=0.001].
|
25613698 |
2015 |