|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, this meta-analysis suggests that Leu432Val polymorphism is associated with ovarian cancer, lung cancer, and endometrial cancer risk; Asn453Ser and Arg48Gly polymorphisms are associated with endometrial cancer risk among Caucasians, Ala119Ser polymorphism is associated with prostate cancer risk, and Ala119Ser polymorphism is associated with breast cancer risk in Caucasians.
|
25475389 |
2015 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The CYP1B1 and ERalpha genes may play a role in endometrial cancer and the Arg48Gly (142C > G) -CYP1B1 and 975C > G-ERalpha polymorphisms may be considered as independent, early diagnostic markers in this disease.
|
20492382 |
2010 |
|
rs10012
|
|
|
0.030 |
GeneticVariation |
BEFREE |
An association of CYP1B1 gene R48G polymorphism with endometrial cancer was found [GG vs. GC+CC: odds ratio (OR)=0.55, 95% confidence interval (CI): 0.42-0.73, P<0.0001; GG vs. CC: OR=0.46, 95% CI: 0.23-0.91, P=0.03].
|
21191305 |
2011 |
|
rs1004446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed an inverse association with IGFII rs3741211 and endometrial cancer risk (OR=0.79 (95% CI: 0.63, 0.99)) and IGFII rs1004446 and endometrial cancer risk (OR=0.80 (95% CI: 0.68, 0.94)).
|
21078522 |
2011 |
|
rs10046
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adjusting for endometrial cancer risk factors, the A allele of rs4775936 in CYP19 was significantly associated (OR(per allele)=1.22, 95% CI=1.01-1.47, p(trend)=0.04), while the T allele of rs10046 was marginally associated with increased risk of endometrial cancer (OR(per allele)=1.20, 95% CI=0.99-1.45, p(trend)=0.06).
|
22633539 |
2012 |
|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA samples from 150 cases of endometrial cancer and healthy controls (n = 165) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the genotypic frequency of 13 different polymorphic loci on the CYP1A1 (m1, m2, m3, m4), CYP1A2 1F, CYP1B1 codon432, COMT codon158, CYP17, SULT1A1 (Arg213His, 14A/G, 85C/T in the 3' flanking region), SULT1E1-64G/A promoter region, and SHBG genes.
|
18318428 |
2008 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In conclusion, we did not observe any evidence for a role of TP53 Arg72Pro polymorphism in endometrial cancer.
|
20552298 |
2011 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer.
|
23624782 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The aim of the study was to determine an association of TP53 codon 72 (Arg72Pro, G>C transversion, rs1042522) and MDM2 SNP309 (T>G change, rs2279744) polymorphisms in endometrial cancer (EC) of postmenopausal women, regarding grading and staging of EC.
|
25316267 |
2014 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
It has been suggested that the p53 tumor suppressor gene Arg72Pro polymorphism is associated with endometrial cancer.
|
22277327 |
2012 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The aim of this study was to detect TP53 Arg72Pro polymorphism in postmenopausal patients with endometrial cancer (EC), to evaluate the risk of EC connected with it, as well to check for possible relationships with staging, grading and some risk factors of this neoplasm.
|
24379271 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Genotype misclassification in genetic association studies of the rs1042522 TP53 (Arg72Pro) polymorphism: a systematic review of studies of breast, lung, colorectal, ovarian, and endometrial cancer.
|
23729685 |
2013 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our data did not demonstrate any significant difference in the prevalence of the p53 Arg72Pro genotype between patients and controls, providing evidence that this polymorphism is only weakly associated with the risk of endometrial cancer and prognostic factors in Caucasian women.
|
19209008 |
2009 |
|
rs1042522
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects.
|
15723718 |
2005 |
|
rs1042838
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings provide empirical evidence that PGR rs1042838 and rs10895068 polymorphisms may be involved in the pathogenesis of endometrial cancer.
|
26881523 |
2016 |
|
rs1045242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs1045242 in the TNFAIP8 gene was strongly associated with with EC risk (adjust OR: 1.636, 95% CI 1.107-2.417, P = 0.014). rs11064 SNPs correlated with TNFAIP8 protein expression in EC (P = 0.015).
|
31043860 |
2019 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our observation suggests that MDR1 C3435T polymorphism is correlated with endometrial cancer susceptibility.
|
17300681 |
2007 |
|
rs1048290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Keap1 single nucleotide polymorphism rs1048290 may be a novel independent prognostic marker for patients with endometrial cancer receiving adjuvant treatment.
|
21897267 |
2011 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that there is no association between endometrial cancer risk and the CYP1A1 Ile462Val polymorphism.
|
23098461 |
2012 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We did not observe any statistically significant associations between the MspI, Thr461Asn or Ile462Val polymorphisms and endometrial cancer risk or any significant effect modification by cigarette-smoking status.
|
17717632 |
2007 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Similarly, Ile462Val polymorphism was not associated with endometrial cancer risk (for heterozygous Ile/Val vs Ile/Ile carriers: OR = 1.27, 95% CI, 0.78-2.06, random effects; for homozygous Val/Val vs Ile/Ile carriers: OR = 1.16, 95% CI, 0.48-2.81, fixed effects).
|
21270613 |
2011 |
|
rs10502289
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype TTG in block 2 of the TYMS gene, which includes SNPs rs10502289, rs2298583, and rs2298581 (located in introns of the ENOSF1 gene), was associated with a marginally significant decrease in risk of endometrial cancer under the dominant model (odds ratio, 0.8; 95% confidence interval, 0.6-1.0).
|
19190136 |
2009 |
|
rs10512263
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Classification and regression tree (CART) demonstrated that women carrying both the genotypes of TGFBR1 rs6478974 TT and rs10512263 TC/CC had the highest risk of EC (aOR = 7.86, 95% CI = 3.42-18.07, P<0.0001).
|
27171242 |
2016 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We did not observe any correlation between the Ser326Cys polymorphism of the hOGG1 gene and endometrial cancer.
|
20602259 |
2011 |
|
rs1056827
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We did not detect any association of CYP1B1 gene A119S polymorphism with endometrial cancer.
|
21191305 |
2011 |