|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively).
|
18957718 |
2008 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The frequency of the protective G-allele of the rs599839 polymorphism was lower in HeFH patients with CHD compared with those HeFH patients without CHD.
|
29714125 |
2018 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
BEFREE |
No significant associations were observed between the other two SNPs in loci 1p13 (rs599839 and rs646776) and CHD mortality in either gender.
|
24728607 |
2014 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
GWASCAT |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Since genome-wide association studies demonstrated association between rs599839 polymorphism and coronary artery disease, in the present study we assessed the potential association of this polymorphism with endothelial dysfunction, an early step in atherogenesis.
|
22380622 |
2012 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
BEFREE |
SORT1 rs599839 was associated with CHD risk (OR 1.20; 1.15-1.26) as well as total- and LDL-cholesterol, and apolipoprotein B. ANGPTL3 rs12042319 was associated with CHD risk (OR 1.11; 1.03, 1.19), total- and LDL-cholesterol, triglycerides, and interleukin-6.
|
21804106 |
2012 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
rs599839
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
rs599839
|
|
A |
0.850 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
rs599839
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In the LURIC Study the G-allele of rs599839 is associated with LDL and TRIG metabolism and the risk of coronary artery disease and myocardial infarction.
|
19837406 |
2010 |
|
rs599839
|
|
A |
0.850 |
GeneticVariation |
GWASDB |
The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212).
|
17634449 |
2007 |
|
rs599839
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212).
|
17634449 |
2007 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
BEFREE |
ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects.
|
30278588 |
2018 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The frequencies of the rs4977574 genotypes and alleles between CHD and control groups, and the rs2740483 genotypes and alleles between IS and control groups were different (p = 0.006-0.001).
|
27096864 |
2016 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Meta-analysis of 23 studies among 36,452 cases and 39,781 controls showed a strong association between rs4977574 and the risk of CHD (p<0.0001, OR=1.27, 95% CI=1.22-1.31).
|
25268619 |
2014 |
|
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Meta-analysis identifies robust association between SNP rs17465637 in MIA3 on chromosome 1q41 and coronary artery disease.
|
24125424 |
2013 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
GWASDB |
A genome-wide association study of a coronary artery disease risk variant.
|
23364394 |
2013 |
|
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Genome-wide association studies have described an association between MIA3 rs17465637 A/C polymorphisms and coronary artery disease and myocardial infarction.
|
22577832 |
2012 |
|
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |