|
rs501120
|
|
|
0.840 |
GeneticVariation |
GWASDB |
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
|
22319020 |
2012 |
|
rs501120
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Because previous genome-wide association studies demonstrated an association between CXCL12 rs501120 and coronary artery disease, in the present study we assessed the potential association of this polymorphism with the risk of cardiovascular (CV) disease in 1,321 Spanish patients with RA.
|
22386691 |
2012 |
|
rs501120
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
rs17465637
|
|
|
0.840 |
GeneticVariation |
BEFREE |
In a genome-wide scan, isolated single nucleotide polymorphisms (SNPs), including rs17465637, in the melanoma inhibitory activity 3 gene (MIA3) on chromosome 1 were identified to be associated with coronary artery disease and myocardial infarction (MI).
|
21264445 |
2011 |
|
rs17465637
|
|
C |
0.840 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
rs17465637
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
rs17465637
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
rs4977574
|
|
G |
0.840 |
GeneticVariation |
GWASCAT |
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
|
21239051 |
2011 |
|
rs4977574
|
|
G |
0.840 |
GeneticVariation |
GWASDB |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
rs4977574
|
|
G |
0.840 |
GeneticVariation |
GWASCAT |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |
|
rs4977574
|
|
G |
0.840 |
GeneticVariation |
GWASDB |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
rs4977574
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
|
rs4977574
|
|
G |
0.840 |
GeneticVariation |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
rs501120
|
|
|
0.840 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
rs501120
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Nine loci were statistically associated with incident CHD events in white participants: 9p21 (rs10757278; P=4.7 × 10(-41)), 16q23.1 (rs2549513; P=0.0004), 6p24.1 (rs499818; P=0.0002), 2q36.3 (rs2943634; P=6.7 × 10(-6)), MTHFD1L (rs6922269, P=5.1 × 10(-10)), APOE (rs429358; P=2.7×10(-18)), ZNF627 (rs4804611; P=5.0 × 10(-8)), CXCL12 (rs501120; P=1.4 × 10(-6)) and LPL (rs268; P=2.7 × 10(-17)).
|
22042884 |
2011 |
|
rs501120
|
|
|
0.840 |
GeneticVariation |
BEFREE |
The results showed that 3 SNPs in whites (rs599839, rs1333049, and rs501120; HRRs were 1.10 (P = 0.044), 1.14 (P < 0.001), and 1.14 (P = 0.030), respectively) and 1 SNP in African Americans (rs7250581; HRR = 1.60, P = 0.05) were significantly associated with incident CHD.
|
19955471 |
2010 |
|
rs17465637
|
|
C |
0.840 |
GeneticVariation |
GWASCAT |
The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212).
|
17634449 |
2007 |
|
rs17465637
|
|
C |
0.840 |
GeneticVariation |
GWASDB |
The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212).
|
17634449 |
2007 |
|
rs501120
|
|
T |
0.840 |
GeneticVariation |
GWASCAT |
The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212).
|
17634449 |
2007 |
|
rs501120
|
|
T |
0.840 |
GeneticVariation |
GWASDB |
The combined analysis of the two studies identified four additional loci significantly associated with coronary artery disease (P<1.3x10(-6)) and a high probability (>80%) of a true association: chromosomes 1p13.3 (rs599839), 1q41 (rs17465637), 10q11.21 (rs501120), and 15q22.33 (rs17228212).
|
17634449 |
2007 |
|
rs174547
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In the secondary analysis, the minor allele of rs174547 in <i>FADS1</i> was associated with significantly lower odds of any ischemic stroke, large-artery stroke, and venous thromboembolism and showed suggestive evidence of inverse association with coronary artery disease, abdominal aortic aneurysm and aortic valve stenosis.
|
31817859 |
2019 |
|
rs10455872
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In the replication cohort, rs10455872 was also associated with CHD events (odds ratio, 1.71; 95% confidence interval, 1.14-2.57; P=0.009).
|
29703846 |
2018 |
|
rs964184
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Our results indicate that both gender and age have great impacts on the association of the rs964184 polymorphism with CHD among Chinese.
|
29339699 |
2018 |
|
rs10455872
|
|
G |
0.830 |
GeneticVariation |
GWASCAT |
Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
|
28753643 |
2017 |