|
rs767649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings support that the rs767649 polymorphism in the pre-MIR155 gene is associated with DR in T2DM and that the miR-155 plasma levels might be associated with T2DM.
|
31751306 |
2019 |
|
rs2281999
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RESULTS There were no significant differences in the distribution of allele or genotype frequencies in the five UNC13B SNP markers (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) between the DKD group and control group of patients with T2DM.
|
31713534 |
2019 |
|
rs200185429
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D).
|
31676859 |
2019 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs7901695
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146</span>, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs11196205
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005).
|
31676834 |
2019 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results indicated that MTHFR C677T polymorphism confers to T2DM, especially in Asian populations.
|
31663297 |
2019 |
|
rs1801133
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR C677T (rs1801133 C>T) polymorphism has been proposed to be linked with type 2 diabetes mellitus (T2DM) susceptibility.
|
31663297 |
2019 |
|
rs11643718
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Arg913Gln variation of SLC12A3 gene is associated with diabetic nephropathy in type 2 diabetes and Gitelman syndrome: a systematic review.
|
31660880 |
2019 |
|
rs1047883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the two significantly associated variants, rs1047883 was newly identified whereas rs2108622 had been previously reported to be associated with T2D-related traits.
|
31652446 |
2019 |
|
rs2108622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One of the two significantly associated variants, rs1047883 was newly identified whereas rs2108622 had been previously reported to be associated with T2D-related traits.
|
31652446 |
2019 |
|
rs1260326
|
|
|
0.770 |
GeneticVariation |
BEFREE |
TWAS found locus chr2q23.3 (rs1260326) was highly pleiotropic among RHR, cardiometabolic traits, and T2D, and identified 7 genes (SMARCAD1, RP11-53O19.3, CTC-498M16.4, PDE8B, AKTIP, KDM4B, and TSHZ3) that were statistically independent and shared between RHR and T2D in tissues from the nervous and cardiovascular systems.
|
31648709 |
2019 |
|
rs10946398
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs7754840
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs4712523
|
|
|
0.830 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs10440833
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs4712524
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We found a significant association between CDKAL1 polymorphisms (rs4712523, OR 1.42, p = 9.44 × 10-5; rs4712524, OR 1.38, p = 3.28 × 10-4; rs10946398, OR 1.43, p = 6.21 × 10-5; rs7754840, OR 1.43, p = 6.33 × 10-5; rs35612982, OR 1.34, p = 0.0010; and rs10440833, OR 1.32, p = 0.0018) and T2D risk among the Han population from Northwest China.
|
31639799 |
2019 |
|
rs35612982
|
|
|
0.710 |
GeneticVariation |
BEFREE |
CDKAL1 rs35612982 (C/T) polymorphism, as a new polymorphism, was associated with the increased risk of T2D in the Han Chinese population.
|
31639799 |
2019 |
|
rs10830963
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between late chronotype and higher risk of T2D appears to vary across MTNR1B rs10830963 genotypes.
|
31623012 |
2020 |
|
rs1800775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96).
|
31597401 |
2019 |
|
rs4783961
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96).
|
31597401 |
2019 |
|
rs328
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We evaluated the influence of CETP (rs5882 and rs708272), APOE (rs7412, rs429358) and LPL (rs328) gene polymorphisms on triglyceride (TG) response to oral fat tolerance test (OFTT) meal in patients with well-controlled type 2 diabetes mellitus (T2DM).
|
31585025 |
2019 |
|
rs708272
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We evaluated the influence of CETP (rs5882 and rs708272), APOE (rs7412, rs429358) and LPL (rs328) gene polymorphisms on triglyceride (TG) response to oral fat tolerance test (OFTT) meal in patients with well-controlled type 2 diabetes mellitus (T2DM).
|
31585025 |
2019 |
|
rs429358
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We evaluated the influence of CETP (rs5882 and rs708272), APOE (rs7412, rs429358) and LPL (rs328) gene polymorphisms on triglyceride (TG) response to oral fat tolerance test (OFTT) meal in patients with well-controlled type 2 diabetes mellitus (T2DM).
|
31585025 |
2019 |