Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs16944
rs16944
0.020 GeneticVariation BEFREE The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively. 21496483

2011

dbSNP: rs1800795
rs1800795
0.020 GeneticVariation BEFREE The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively. 21496483

2011

dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE In this study, we sought to determine whether a functional genetic variation in a prominent proinflammatory cytokine, tumor necrosis factor-alpha (TNFA-308G>A [rs1800629] promoter polymorphism) was associated with overall ratings of sleep disturbance and fatigue as well as with the trajectories of these symptoms. 19419979

2009

dbSNP: rs1800562
rs1800562
0.020 GeneticVariation BEFREE Male C282Y homozygotes with a serum ferritin level of 1000 mug per liter or more were more likely to report fatigue, use of arthritis medicine, and a history of liver disease than were men who had the wild-type gene. 18199861

2008

dbSNP: rs387907170
rs387907170
0.010 GeneticVariation BEFREE Siblings with the common myopathic ETFDH c.1130T>C mutation presented with a new phenotype dominated by chronic fatigue without apparent myopathy. 31331668

2019

dbSNP: rs4570625
rs4570625
0.010 GeneticVariation BEFREE Only one SNP, TPH2 rs4570625, was significantly associated with fatigue ( p = .005). 30309244

2019

dbSNP: rs1289543302
rs1289543302
0.010 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018

dbSNP: rs25531
rs25531
0.010 GeneticVariation BEFREE Susceptibility and severity of cancer-related fatigue in colorectal cancer patients is associated with SLC6A4 gene single nucleotide polymorphism rs25531 A>G genotype. 29551185

2018

dbSNP: rs3740071
rs3740071
0.010 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018

dbSNP: rs1042718
rs1042718
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs1212171
rs1212171
0.010 GeneticVariation BEFREE Genotype at the NTRK2 SNP rs1212171 was associated with both sleep disturbance and fatigue. 28205449

2017

dbSNP: rs17841327
rs17841327
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs2293052
rs2293052
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs34778348
rs34778348
0.010 GeneticVariation BEFREE Overall, we found that carriers of the G2385R variant were more prone to fatigue than non-carriers in PD patients. 28941828

2017

dbSNP: rs3783642
rs3783642
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs4646437
rs4646437
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs6265
rs6265
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs9332377
rs9332377
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs949060
rs949060
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs9658498
rs9658498
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs11214105
rs11214105
0.010 GeneticVariation BEFREE A 5' UTR polymorphism (rs11214105) in IL18 also associated with physical fatigue, body pain and score for CFS case defining symptoms. 26116897

2015

dbSNP: rs4251961
rs4251961
0.010 GeneticVariation BEFREE The C allele of the rs4251961 single nucleotide polymorphism (SNP) in IL1RN was associated with self-reported fatigue (P = .03), whereas the cosegregating polymorphisms in TLR4 were associated with lower levels of fatigue (P= .04). 25542762

2015

dbSNP: rs1217691063
rs1217691063
0.010 GeneticVariation BEFREE Investigation of MTHFR C677T gene polymorphism, biochemical and clinical parameters in Turkish migraine patients: association with allodynia and fatigue. 23975093

2013

dbSNP: rs3087243
rs3087243
0.010 GeneticVariation BEFREE Besides, patients carrying A allele of rs3087243 had significantly lower score of fatigue domain than those carrying G allele (2.5 ± 0.8 vs 3.9 ± 1.3, P < 0.001). 23432218

2013

dbSNP: rs1991517
rs1991517
0.010 GeneticVariation BEFREE The modest effect of the TSHR-Asp727Glu polymorphism on fatigue in DTC patients should be confirmed in other cohorts. 22989469

2012