|
rs121913682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six other patients reported symptomatic improvement, including two with D816V KIT mutation-positive SM (one reported improvement in diarrhea and the other in fatigue).Other patients had no benefit.Imatinib was relatively well tolerated.
|
19193436 |
2009 |
|
rs574584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mexican patients with the rs574584 GG genotype presented the highest FIQ score compared with Mexican patients with other genotypes (P = 0.01), and in Mexicans SNP rs574584 was associated with FIQ morning stiffness (P = 0.04) and with FIQ tiredness upon awakening (P = 0.02).
|
19565482 |
2009 |
|
rs151344517
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Missense mutations in the AFG3L2 proteolytic domain account for ∼1.5% of European autosomal dominant cerebellar ataxias.
|
20725928 |
2010 |
|
rs1082214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We obtained supported evidence for involvement of TIMELESS in sleeping problems in an independent set of control individuals with seasonal changes in mood, sleep duration, energy level and social activity in females (P = 0.036, = 0.123 for rs1082214) and with early morning awakening or fatigue in males (P = 0.038 and P = 0.0016, respectively, for rs1082214).
|
20174623 |
2010 |
|
rs121912438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
If activity-dependent conversion of motor units to more fatigue resistant types increased their resilience and hence survival, we hypothesized that an experimental increase in motor unit activity in the hindlimb muscles of the SOD1(G93A) transgenic mouse should "save" those motor units that are normally lost in the first 90 days of age.
|
19879358 |
2010 |
|
rs2295633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes at rs3766246 and rs2295633 were significantly associated with increased ratings of Arousal (p<0.05) and Fatigue</span> (p<0.01) after the 10-mg dose.
|
19890266 |
2010 |
|
rs3766246
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes at rs3766246 and rs2295633 were significantly associated with increased ratings of Arousal (p<0.05) and Fatigue (p<0.01) after the 10-mg dose.
|
19890266 |
2010 |
|
rs4719714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An evaluation was done on whether genetic variation in a prominent proinflammatory cytokine, interleukin-6 (IL-6 c.-6101A>T [rs4719714]), was associated with mean ratings of evening fatigue, morning fatigue, and sleep disturbance, as well as with the trajectories of these symptoms.
|
20570482 |
2010 |
|
rs570874680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mutations in the γ2 subunit have implications for cardiac function and disease, while the R225W mutation in the γ3 subunit have implications for skeletal muscle fuel metabolism and resistance to fatigue.
|
21031502 |
2010 |
|
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
|
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
|
rs2794521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
|
rs3091244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a large cohort of BCSs the investigated SNPs in inflammation-related genes were not associated with fatigue, though subset analyses indicated an association between the CRP SNP (rs3091244) and serum hsCRP.
|
21496483 |
2011 |
|
rs4129267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
|
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
IL1B-511 (rs16944) genotype did not significantly predict changes in fatigue (p values >0.46).
|
22475653 |
2012 |
|
rs1800629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with the TNFA-308 (rs1800629) G/A genotype showed greater increases in fatigue severity than the G/G genotype (p = 0.02).
|
22475653 |
2012 |
|
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and duration than the G/G genotype (p values ≤ 0.05), although inclusion of age, race, and baseline depressive symptomatology in the model attenuated these relationships (p values ≤ 0.09).
|
22475653 |
2012 |
|
rs1991517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The modest effect of the TSHR-Asp727Glu polymorphism on fatigue in DTC patients should be confirmed in other cohorts.
|
22989469 |
2012 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
|
rs224222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis according to clinical features for this disease reveals that morning fatigue and irritable bowel syndrome had associations with R202Q polymorphism (p=0.022 and p=0.031 respectively).
|
23010357 |
2012 |
|
rs2287396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs2287396 [GSTZ1] and rs9524885 [ABCC4]) from glutathione metabolic pathway were associated with fatigue in unadjusted analysis.
|
22454423 |
2012 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
|
21898113 |
2012 |
|
rs9524885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs2287396 [GSTZ1] and rs9524885 [ABCC4]) from glutathione metabolic pathway were associated with fatigue in unadjusted analysis.
|
22454423 |
2012 |