|
rs10464870
|
|
G |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs1048771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the single-locus analysis, two variants, the NBS1 rs1805794 (OR 1.42, 95% CI 1.15-1.76, P = 0.001), and RAD54L rs1048771 (OR 1.61, 95% CI 1.17-2.22, P = 0.002) were significantly associated with glioma risk.
|
26514363 |
2016 |
|
rs104894104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In order to test the candidacy of p16beta as a glioma suppressor, we replaced p16(INK4a), p15(INK4b) and p16beta wild-type as well as a series of seven glioma-derived p16beta alleles (R87H, A112V, R120H, A121V, G125R, A128A and A128V), into glioma cell lines that had either CDKN2A-/RB+ (U-87MG and U-251MG) or CDKN2A+/RB- (LN-319) endogenous backgrounds and demonstrated that p16beta can act as a functional glioma cell growth suppressor.
|
9366518 |
1997 |
|
rs104894156
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|
|
rs1049353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results Genotypic distribution of the G1359A CNR1 polymorphism in glioma patients showed significant differences when compared to the control group.
|
21156413 |
2010 |
|
rs10494090
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
|
19578366 |
2009 |
|
rs10506868
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer.
|
28949031 |
2018 |
|
rs10519097
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Study distribution by tumor was as follows: breast cancer (n=15), prostate cancer (n=3), pancreatic cancer (n=2), non-Hodgkin's lymphoma (n=2), glioma (n=1), chronic lymphocytic leukemia (n=1), colorectal cancer (n=1), non-small cell lung cancer (n=1) and ovarian cancer (n=1).We identified 10 single nucleotide polymorphisms (SNPs) significantly associated with cancer risk: NPAS2 rs10165970 (mixed and breast cancer shiftworkers), rs895520 (mixed), rs17024869 (breast) and rs7581886 (breast); CLOCK rs3749474 (breast) and rs11943456 (breast); RORA rs7164773 (breast and breast cancer postmenopausal), rs10519097 (breast); RORB rs7867494 (breast cancer postmenopausal), PER3 rs1012477 (breast cancer subgroups) and assessed the level of quality evidence to be intermediate.
|
28177907 |
2017 |
|
rs1052555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no evidence was found in analyses for the association between other 3 ERCC2 polymorphisms (rs238406, rs1799793, and rs1052555) and susceptibility to glioma development.
|
24969862 |
2014 |
|
rs1052576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP-9 (rs1052576) mutant A allele seems to be a protective factor for glioma brain tumor.
|
28870924 |
2017 |
|
rs1053667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study evaluated the role of TYMS (rs1059394, C > T, and rs2847153, G > A), RYR3 (rs1044129, G > A), KIAA0423 (rs1053667, T > C), and GOLGA7 (rs11337, G > T) polymorphisms for assessment of glioma risk and prognosis among the Chinese Han population.
|
31525662 |
2019 |
|
rs1057519902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report the case of a 17-year-old female with an H3F3A G34R mutated infiltrative glioma who developed painful osseous metastases to her pelvis and spine within 3 months of clinical presentation.
|
31139567 |
2019 |
|
rs1057519903
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Despite the presence of H3 K27M mutations, these cases should not be graded and treated as grade IV tumors because they have a better spontaneous outcome than classic diffuse midline H3 K27M-mutant glioma.
|
27984673 |
2018 |
|
rs1057519903
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Five (12 %) low grade and 11 (50 %) high grade gliomas were positive for the H3F3A/HIST1H3B K27M (H3K27M) mutation.
|
27577993 |
2016 |
|
rs1057519903
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No significant prognostic value was observed for grade, even after regrading H3F3A K27M-mutated midline glioma as grade IV (WHO 2016).
|
31419298 |
2020 |
|
rs1057519903
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Whereas both H3F3A K27M and BRAF V600E have been reported as poor prognostic markers in pediatric glioma, our case, along with several other reported cases, suggests that the coexistence of these two mutations might not indicate poor prognosis.
|
31254135 |
2019 |
|
rs1057519903
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Pediatric thalamic glioma with H3F3A K27M mutation, which was detected before and after malignant transformation: a case report.
|
27392443 |
2016 |
|
rs1058319
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among 99 SNPs, five independent susceptibility loci (20-62315594 in RTEL1, 20-62335293 in adenosine diphosphate ribosylation factor-related protein 1, rs3761121 in ZGPAT, rs1058319 in SLC2A4RG and rs5019252 in ZBTB46) were identified for glioma.
|
22387365 |
2012 |
|
rs1059394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our study provides evidence of the effect of <i>TYMS</i> rs1059394 on the susceptibility of glioma.
|
31632074 |
2019 |
|
rs1059394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that GOLGA7 (rs11337) polymorphism may play a role in the prognosis of glioma patients and that TYMS (rs1059394) is associated with glioma risk.
|
31525662 |
2019 |
|
rs1059513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This population-based case-control study aimed to find potential association between single nucleotide polymorphisms IL-13rs20541, IL-4Rars1801275 and glioma susceptibility in population, as well as STAT6 rs1059513 and STAT6 rs324015.
|
21196282 |
2011 |
|
rs1063192
|
|
|
0.710 |
GeneticVariation |
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
rs1063192
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
rs1063192
|
|
|
0.710 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
rs1064794096
|
|
|
0.700 |
GeneticVariation |
UNIPROT |
|
|
|