|
rs1320702652
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Possession of the C34T (Glu12Stop) nonsense mutation in the AMP-deaminase 1 (AMPD1) gene has been shown to be associated with improved prognosis in heart failure and ischemic heart disease.
|
14499869 |
2003 |
|
rs1320702652
|
|
|
0.040 |
GeneticVariation |
BEFREE |
C34T AMPD1 polymorphism may be associated with reduced frequency of obesity in CAD patients and of hyperglycaemia and diabetes in both CAD and HF patients.
|
18855224 |
2009 |
|
rs1320702652
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease.
|
16021915 |
2005 |
|
rs1337916669
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A rare S65C mutation and a novel A271S mutation were also found in this study; the latter patient had 4+ iron in the liver and later developed heart failure with cardiac iron.
|
20208481 |
2010 |
|
rs1344172059
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs140226130
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included signs related to both ATTRm and ATTRwt such as chronic ischaemic heart disease (rs140226130, p = 2.00 × 10<sup>-6</sup>), heart failure (rs73956431, p = 2.74 × 10<sup>-6</sup>), atrial fibrillation (rs10163755, p = 4.63 × 10<sup>-6</sup>), dysphagia (rs2949506, p = 3.95 × 10<sup>-6</sup>), intestine diseases (rs970866, p = 7.14 × 10<sup>-6</sup>) and anxiety (rs554521234, p = 8.85 × 10<sup>-6</sup>).
|
31659433 |
2019 |
|
rs141322087
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1429117513
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 350 subjects enrolled in the genetic substudy (GRAHF [Genetic Risk Assessment of Heart Failure in African Americans]) were genotyped for the C825T polymorphism.
|
25306451 |
2014 |
|
rs150821281
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, combining epidemiological data, with data on patients referred for genetic testing for ARVC or HCM/DCM, and data from in vitro studies, PKP2 c.419C>T did not associate with heart failure, arrhythmias, or premature death, with ARVC or HCM/DCM, or with effects in vitro, suggesting that this is not a disease-causing variant.
|
26264440 |
2016 |
|
rs1535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found little evidence of an association between ALA and CHF in subgroups based on age, sex, diabetes, fish consumption, BMI, or FADS2 genotype (rs1535).
|
22743310 |
2012 |
|
rs1544223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, the rs1544223 was significantly associated with CHF risk under the dominant model (<i>P</i> = 0.046, OR = 1.662, 95% CI = 1.009-2.738).But it did not affect disease severity.
|
29955603 |
2018 |
|
rs1553265736
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1559279177
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1595064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-G-C-C-T haplotype of rs10932374-rs13003941-rs1595064-rs1595065-rs3748960 in the ErbB4 gene increased the risk of heart failure (odd ratio 1.35, 95% confidence interval [CI] 1.06-1.70; P = .014).
|
26844763 |
2016 |
|
rs1595065
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-G-C-C-T haplotype of rs10932374-rs13003941-rs1595064-rs1595065-rs3748960 in the ErbB4 gene increased the risk of heart failure (odd ratio 1.35, 95% confidence interval [CI] 1.06-1.70; P = .014).
|
26844763 |
2016 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, carriers of at least one variant <i>GSTP1</i>∗Val (rs1695) allele were at 1.7-fold increased HF risk than <i>GSTP1</i>∗Ile/Ile carriers (<i>p</i> = 0.031), which was higher when combined with the variant <i>GSTA1</i>∗B allele (OR = 2.2, <i>p</i> = 0.034).
|
31275451 |
2019 |
|
rs1739843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two intronic single-nucleotide polymorphisms showed replicated associations with all-cause heart failure as follows: rs1739843 in HSPB7 (combined P=3.09x10(-6)) and rs6787362 in FRMD4B (P=6.09x10(-6)).
|
20124441 |
2010 |
|
rs17740607
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against CHF, which provides novel highlights for investigating the contribution of CHF.
|
25846768 |
2015 |
|
rs17859821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).
|
19295411 |
2009 |
|
rs17859821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The findings of the present study suggest that MMP-2 rs17859821 A allele was associated with better prognosis of systolic HF in the northern Han Chinese population.
|
19332048 |
2009 |
|
rs1799752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated nuclear factor kappa B {NFkB, rs28362491 [-94ins/delATTG (W/D)]} and angiotensin converting enzyme {ACE; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF).
|
23543433 |
2014 |
|
rs1799895
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease.
|
25927599 |
2015 |
|
rs1799895
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Risk of cardiovascular disease and heart failure was higher in R213G heterozygotes versus non-carriers in diabetic subjects, but not in non-diabetic subjects.
|
26844281 |
2015 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis revealed that the odds of CHF was higher in females [Odds Ratio (OR) = 2·9, P < 0·01], individuals with pre-HCT chest radiation (OR = 4·7, P = 0·05), hypertension (OR = 2·9, P = 0·01), and with variants of genes coding for the NAD(P)H-oxidase subunit RAC2 (rs13058338, 7508T→A; OR = 2·8, P < 0·01), HFE (rs1799945, 63C→G; OR = 2·5, P = 0·05) or the doxorubicin efflux transporter ABCC2 (rs8187710, 1515G→A; OR = 4·3, P < 0·01).
|
23927520 |
2013 |
|
rs1799983
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Homozygosity for the G allele of the eNOS G894T polymorphism was associated with worse survival in systolic HF patients, especially in those treated with nitrates.
|
25917853 |
2015 |