|
rs8193037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether the IL-17A -737 T/C (rs8193036), -444A/G (rs3819024), -197G/A (rs2275913), and -121G/A (rs8193037) SNPs conferred susceptibility to SLE (or lupus nephritis) or to RA in a Mexican population.
|
30398030 |
2019 |
|
rs1799964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population.
|
29611038 |
2018 |
|
rs3824662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GATA3 rs3824662 is not associated with susceptibility to SLE either in adult or in pediatric patients; however, in pSLE patients, the heterozygous AC genotype could be considered a risk factor for LN.
|
30301440 |
2018 |
|
rs8091180
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs8091180 in NFATC1 was associated with LN (OR 1.43, p = 3.3E-04) in the candidate SNP meta-analysis with the highest OR among African-Americans (OR 2.17, p = 0.0035).
|
29953444 |
2018 |
|
rs1061170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significantly higher ratio of CC/CT genotypes of rs1061170 in lupus nephritis patients with class III than in the other two classes (class III vs. class IV vs. class V: 21.0% vs. 9.7% vs. 9.4%; P = .044).
|
28403670 |
2017 |
|
rs114580964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We discovered five independent risk variants for LN within the MHC region, including <i>HLA-DRβ1</i> amino acid 11 (<i>P</i><sub>omnibus</sub><0.001), <i>HLA-DQβ1</i> amino acid 45 (<i>P</i><0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), <i>HLA-A</i> amino acid 156 (<i>P</i><sub>omnibus</sub><0.001), <i>HLA-DPβ1</i> amino acid 76 (<i>P</i><sub>omnibus</sub><0.001), and a missense variant in <i>PRRC2A</i> (rs114580964; <i>P</i><0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance.
|
28754791 |
2017 |
|
rs1456896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the rs1456896 A allele is associated with protective susceptibility to LN.
|
27684961 |
2017 |
|
rs3746444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first report documenting that the <i>miR-146a</i> rs2910164G/C and <i>miR-499</i> rs3746444 polymorphisms are associated with SLE susceptibility but not with LN.
|
29190882 |
2017 |
|
rs5744168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No allelic nor genotype association was found with TLR-5-rs5744168 in SLE. but the T allele and the TT genotype were raised significantly in the LN group (P < 0·05).
|
28763101 |
2017 |
|
rs6677604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs6677604-GG genotype was observed to be associated with the absence of anti-ds DNA antibody ( P = .021), and the rs800292-TT genotype was associated with a higher level of circulating C3 ( P = 0.20) in lupus nephritis.
|
28403670 |
2017 |
|
rs800292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs6677604-GG genotype was observed to be associated with the absence of anti-ds DNA antibody ( P = .021), and the rs800292-TT genotype was associated with a higher level of circulating C3 ( P = 0.20) in lupus nephritis.
|
28403670 |
2017 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |
|
rs2397084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |
|
rs329498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Likewise, the rs329498 SNP was also associated with the clinical features LN and malar rash in SLE patients.
|
27018966 |
2016 |
|
rs3792192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PLA2R1 displayed a nominally significantly genetic association with SLE [for rs4664308, P = 0.02, odds ratio (OR) 1.16, 95 % confidence interval (CI) 1.02-1.31; for rs3792192, P = 7.9 × 10(-3), OR 1.18, 95 % CI 1.05-1.34] and LN (for rs4664308, P = 0.04).
|
26645973 |
2016 |
|
rs4664308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PLA2R1 displayed a nominally significantly genetic association with SLE [for rs4664308, P = 0.02, odds ratio (OR) 1.16, 95 % confidence interval (CI) 1.02-1.31; for rs3792192, P = 7.9 × 10(-3), OR 1.18, 95 % CI 1.05-1.34] and LN (for rs4664308, P = 0.04).
|
26645973 |
2016 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |
|
rs11893826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 111 patients with SLE (50 with SLE without nephritis, 55 with LN and 6 with simple urinary sediment abnormalities) and 62 healthy controls (HC) were genotyped for NCX1 rs11893826 (NCX1a) and rs434082 (NCX1b) and ADD2 rs4984 SNPs.
|
26045217 |
2015 |
|
rs1391441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs17008504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs172378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results support the implication of the G allele in rs172378 as a risk factor for lupus nephritis in a homozygous status, at least for a Bulgarian population.
|
25326229 |
2015 |
|
rs2271100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs2295415
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2295415 appears to confer higher risk to develop anti-Sm antibodies-positive SLE and may play a protective role against lupus nephritis.
|
26601115 |
2015 |
|
rs28940579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The prevalence of four MEFV gene mutations (M694V, M680I, V726A and E148Q) was investigated in 114 SLE patients and effect on disease severity was analyzed in patients with biopsy-proven SLE nephritis.
|
25413357 |
2015 |
|
rs292001
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele and AA genotype of C1q rs292001 can be considered a susceptibility risk factor and the GG genotype could be considered protective for jSLE and LN in the studied cohort of Egyptian children.
|
26095468 |
2015 |