|
rs4880
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Val(16)Ala polymorphism is related to gastric cancer development.
|
20233853 |
2010 |
|
rs4986790
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Asp299Gly and Thr399Ile polymorphisms in TLR4 have been associated with a variety of inflammatory and infectious conditions including gastric cancer.
|
24295404 |
2014 |
|
rs11671784
|
|
|
0.020 |
GeneticVariation |
BEFREE |
rs11671784 G/A and rs895819 A/G polymorphisms inversely affect gastric cancer susceptibility and miR-27a expression in a Chinese population.
|
25399405 |
2014 |
|
rs2910164
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs2910164 of miR-146a is associated with GC.
|
27267319 |
2016 |
|
rs2990245
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs2990245 is significantly associated with a decreased risk of GC.
|
30951202 |
2019 |
|
rs12416605
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs12416605:C>T in MIR938 associates with gastric cancer through affecting the regulation of the CXCL12 chemokine gene.
|
31273931 |
2019 |
|
rs8193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs8193 is statistically associated with the risk of malignancy, lymph node spread and stage of gastric cancer in Iranian population.
|
31376327 |
2020 |
|
rs8113645
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A allele genotypes of rs8113645</span> and G allele genotypes of rs2288947 (rs8113645 GA and AA; rs2288947 AG and GG) were also significantly associated with decreased GC risk (p < 0.05).
|
27893425 |
2016 |
|
rs2288947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A allele genotypes of rs8113645 and G allele genotypes of rs2288947 (rs8113645 GA and AA; rs2288947 AG and GG) were also significantly associated with decreased GC risk (p < 0.05).
|
27893425 |
2016 |
|
rs10680577
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study, including 415 GC patients and 830 healthy controls, was conducted to investigate the association between GC susceptibility with a 4-bp insertion/deletion polymorphism (rs10680577) in the proximal promoter of EGLN2.
|
24517638 |
2014 |
|
rs4719839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional genetic variant of miRNA rs4719839 and the corresponding haplotype were associated with clinicopathological features and prognosis of advanced GCs.
|
25261463 |
2014 |
|
rs1048943
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A great number of studies regarding the association between MspI and Ile462Val polymorphisms in the CYP1A1 gene and gastric cancer have been published.
|
22359202 |
2012 |
|
rs1229984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk.
|
22144473 |
2012 |
|
rs112754928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A low-frequency missense variant rs112754928 in the SPOC domain containing 1 gene (SPOCD1; encoding p.Arg71Trp), at 1p35.2, was reproducibly associated with reduced risk of gastric cancer (odds ratio, 0.56; P = 3.48 × 10<sup>-8</sup>).
|
28246015 |
2017 |
|
rs3748068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A meaningful interaction among ever smoked, family history of GC, and rs3748068 could intensify GC risk by 2.25-fold.
|
29118466 |
2017 |
|
rs74483926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A missense mutation (S3660L) in MLL3 gene influences risk of gastric cancer.
|
24965397 |
2014 |
|
rs744154
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A non-significant increased risk of gastric cancer was found in individuals carrying the rs744154 GG genotype.
|
23679285 |
2013 |
|
rs2274223
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34).
|
20729852 |
2010 |
|
rs2910164
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was found between rs2910164</span> and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71-0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73-0.91) for the total data.
|
26202478 |
2017 |
|
rs3748067
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A significant interaction was observed between the rs2275913G>A and rs3748067C>T genotype and subsites of gastric cancer (p for interaction of 0.044 and 0.008, respectively).
|
24218334 |
2014 |
|
rs920778
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma.
|
31759985 |
2020 |
|
rs13181
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A statistically significant finding could be seen in noncardia-type gastric cancer for XPD Lys751Gln polymorphism.
|
23028453 |
2012 |
|
rs671
|
|
|
0.070 |
GeneticVariation |
BEFREE |
A stratified analysis by country showed that the ALDH2 rs671 G>A polymorphism might be a risk factor for GC in Japan (Allele model: <i>P</i><sub>unadjusted</sub> = 0.034; Dominant model: <i>P</i><sub>unadjusted</sub> = 0.040); however, the result was nonsignificant when the Bonferroni correction and false discovery rate (FDR) were applied.
|
29254255 |
2017 |
|
rs12615966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC</span> under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively).
|
28404937 |
2017 |
|
rs2689154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively).
|
28404937 |
2017 |