rs11012732
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)).
|
21804547 |
2011 |
rs11012732
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)).
|
21804547 |
2011 |
rs11012732
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)).
|
21804547 |
2011 |
rs2686876
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9).
|
29762745 |
2018 |
rs2686876
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9).
|
29762745 |
2018 |
rs1568234664
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CASP8 D302H polymorphism genotypic frequencies were not statistically significantly different between meningioma cases and controls, with frequencies of GG, GC and CC genotypes of 71.2%, 19,2% and 9.6%; and 57.9%, 36.8% and 5.3%, respectively.
|
26359420 |
2016 |
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively).
|
18823701 |
2009 |
rs121434592
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Mutations in <i>NF2, TRAF7, SMO, KLF4</i>, and <i>AKT1</i> E17K did not predict RB1 S780 staining or progression in grade 1.5 meningiomas.
|
31615938 |
2020 |
rs121434592
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways.
|
23334667 |
2013 |
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The current meta-analysis firstly provides evidence that the MTHFR C677T polymorphism may modify the risk for brain tumors, particularly meningioma.
|
23846816 |
2013 |
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
C677T gene polymorphism of methylenetetrahydrofolate reductase (MTHFR) in meningiomas and high-grade gliomas.
|
16821630 |
2006 |
rs12770228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
rs12770228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant 'A' allele in MLLT10 rs12770228 was associated with an increased risk of meningioma (per allele odds ratio: 1.25; 95% confidence interval: 1.02, 1.53; P=0.031).
|
24755950 |
2015 |
rs1801131
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
rs1801131
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |
rs1801394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meni</span>ngioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023).
|
28915669 |
2017 |
rs1801394
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
rs4968451
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphisms rs4968451T>G in BRIP1 were significantly associated with the risk of meningioma (TT vs. TG vs. GG additive, P = 0.005; TT+TG vs. GG dominant, P = 0.015; TT/GT+GG recessive, P = 0.034).
|
29581016 |
2018 |
rs4968451
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have identified a novel association between rs4968451 and meningioma risk.
|
18270339 |
2008 |
rs1035938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significantly increased risk of meningioma with the T variant of GLTSCR1 rs1035938 (OR(CT/TT) = 3.5; 95% confidence interval: 1.8-6.9; P(trend) .0006), which persisted after controlling for multiple comparisons (P = .019).
|
20150366 |
2010 |
rs1056836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CYP1B1 V432L homozygous variant was associated with decreased risk of meningioma (odds ratio [OR] = 0.6; 95% CI, 0.3-1.0) but not the other tumor types.
|
16598069 |
2006 |
rs10936599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III.
|
27350555 |
2016 |
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III.
|
27350555 |
2016 |