|
rs10936599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs150766139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The carrier of c.268C>T (p.Q90*) and 550-1G>A was diagnosed with CRC and meningioma at ages 37 and 45 respectively, being reclassified as attenuated adenomatous polyposis after the cumulative detection of 26 adenomas.
|
31227763 |
2019 |
|
rs2235544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C-allele of the DI01 SNP rs2235544 was related to increased circulating free T3/ free T4 ratio in glioma and meningioma patients, indicating greater T4 to T3 conversion.
|
31452060 |
2019 |
|
rs2736100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs3731249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report an undescribed p.(Ala148Thr) CDKN2A mutation in meningioma that was only present in relapsing tumors.
|
31729637 |
2019 |
|
rs603965
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, in stratified analyses by type of disease, we noticed that the rs603965 polymorphism was significantly associated with the susceptibility to glioma, but such positive results were not detected in pituitary adenoma or meningioma.
|
30972946 |
2019 |
|
rs9420907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III.
|
27350555 |
2016 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III.
|
27350555 |
2016 |
|
rs1243180
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped two tightly linked single-nucleotide polymorphisms (SNPs) at MLLT10 associated with meningioma (rs12770228) or ovarian cancer (rs1243180), and tested for associations among 295 meningioma cases, 606 glioma cases and 646 noncancer controls, all of European descent.
|
24755950 |
2015 |
|
rs121918347
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways.
|
23334667 |
2013 |
|
rs17655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
rs1799782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
rs202247756
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We combined genome-wide linkage analysis and exome sequencing, and we identified in suppressor of fused homolog (Drosophila), SUFU, a c.367C>T (p.Arg123Cys) mutation segregating with the meningiomas in the family.
|
22958902 |
2012 |
|
rs267606541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor.
|
22527616 |
2012 |
|
rs1035938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significantly increased risk of meningioma with the T variant of GLTSCR1 rs1035938 (OR(CT/TT) = 3.5; 95% confidence interval: 1.8-6.9; P(trend) .0006), which persisted after controlling for multiple comparisons (P = .019).
|
20150366 |
2010 |
|
rs1800067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).
|
20150366 |
2010 |
|
rs1805794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The NBN rs1805794 minor allele variant was associated with decreased meningioma risk (P(trend) .006).
|
20150366 |
2010 |
|
rs25406
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).
|
20150366 |
2010 |
|
rs3219466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).
|
20150366 |
2010 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of the PON1 genotypes and allelic variants of the polymorphisms PON1 L55M and PON1 Q192R did not differ significantly between patients with astrocytoma and meningioma and controls.
|
20723250 |
2010 |
|
rs7574920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the same GPX1 polymorphisms and XDH rs7574920 were found to significantly modify the association between cumulative lead exposure and meningioma.
|
19505917 |
2009 |