|
rs2686876
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9).
|
29762745 |
2018 |
|
rs2686876
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9).
|
29762745 |
2018 |
|
rs267606541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor.
|
22527616 |
2012 |
|
rs121434592
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Mutations in <i>NF2, TRAF7, SMO, KLF4</i>, and <i>AKT1</i> E17K did not predict RB1 S780 staining or progression in grade 1.5 meningiomas.
|
31615938 |
2020 |
|
rs121434592
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways.
|
23334667 |
2013 |
|
rs1035938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significantly increased risk of meningioma with the T variant of GLTSCR1 rs1035938 (OR(CT/TT) = 3.5; 95% confidence interval: 1.8-6.9; P(trend) .0006), which persisted after controlling for multiple comparisons (P = .019).
|
20150366 |
2010 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III.
|
27350555 |
2016 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data suggest routine screening for BRAF V600E mutations for glioblastomas WHO grade IV below the age of 30, especially in glioblastomas with epithelioid features and in all rhabdoid meningiomas WHO grade III.
|
27350555 |
2016 |
|
rs4968451
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphisms rs4968451T>G in BRIP1 were significantly associated with the risk of meningioma (TT vs. TG vs. GG additive, P = 0.005; TT+TG vs. GG dominant, P = 0.015; TT/GT+GG recessive, P = 0.034).
|
29581016 |
2018 |
|
rs4968451
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have identified a novel association between rs4968451 and meningioma risk.
|
18270339 |
2008 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CASP8 D302H polymorphism genotypic frequencies were not statistically significantly different between meningioma cases and controls, with frequencies of GG, GC and CC genotypes of 71.2%, 19,2% and 9.6%; and 57.9%, 36.8% and 5.3%, respectively.
|
26359420 |
2016 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively).
|
18823701 |
2009 |
|
rs603965
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, in stratified analyses by type of disease, we noticed that the rs603965 polymorphism was significantly associated with the susceptibility to glioma, but such positive results were not detected in pituitary adenoma or meningioma.
|
30972946 |
2019 |
|
rs1329443726
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two anaplastic meningiomas carried somatic point mutations in CDKN2A (c.262G>T: E88X and c.262G>A: E88K) and p14(ARF) (c.305G>T: G102V and c.305G>A: G102E).
|
11485924 |
2001 |
|
rs3731249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report an undescribed p.(Ala148Thr) CDKN2A mutation in meningioma that was only present in relapsing tumors.
|
31729637 |
2019 |
|
rs1475218156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two anaplastic meningiomas carried somatic point mutations in CDKN2A (c.262G>T: E88X and c.262G>A: E88K) and p14(ARF) (c.305G>T: G102V and c.305G>A: G102E).
|
11485924 |
2001 |
|
rs1056836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CYP1B1 V432L homozygous variant was associated with decreased risk of meningioma (odds ratio [OR] = 0.6; 95% CI, 0.3-1.0) but not the other tumor types.
|
16598069 |
2006 |
|
rs2235544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C-allele of the DI01 SNP rs2235544 was related to increased circulating free T3/ free T4 ratio in glioma and meningioma patients, indicating greater T4 to T3 conversion.
|
31452060 |
2019 |
|
rs1568234664
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1800067
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Significantly increased meningioma risk was also observed for the minor allele variants of ERCC4 rs1800067 (P(trend) .01); MUTYH rs3219466 (P(trend) .02), and PCNA rs25406 (P(trend) .03).
|
20150366 |
2010 |
|
rs17655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study has shown that XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC3 Thr241Met and ERCC5 Asp1558His are associated with risk of gliomas and meningiomas.
|
23534771 |
2013 |
|
rs12770228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
rs12770228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant 'A' allele in MLLT10 rs12770228 was associated with an increased risk of meningioma (per allele odds ratio: 1.25; 95% confidence interval: 1.02, 1.53; P=0.031).
|
24755950 |
2015 |
|
rs11012732
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)).
|
21804547 |
2011 |