|
rs13361160
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
|
22956598 |
2013 |
|
rs13361160
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.
|
22956598 |
2013 |
|
rs17122021
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs17122021
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs2562456
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs2562456
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs1057518927
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1057518946
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs121908552
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1554781700
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1972597
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study suggests common variants within RP11-634B7.4 gene influencing severe pre-treatment pain in head and neck cancer patients.
|
27670397 |
2016 |
|
rs3862188
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
We identified 3 common genetic variants in high linkage disequilibrium for severe pre-treatment pain, representing one genomic region at 1q44 (rs3862188, P = 3.45 × 10<sup>-8</sup>; rs880143, P = 3.45 × 10<sup>-8</sup>; and rs7526880, P = 4.92 × 10<sup>-8</sup>), which maps to the RP11-634B7.4 gene, a novel antisense gene to three olfactory receptor genes.
|
27670397 |
2016 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic variants in OPRM1, particularly the non-synonymous polymorphism A118G, have been repeatedly associated with the efficacy of treatments for pain and various types of dependence.
|
24201053 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most pronounced N40D effects were found in brain regions involved in the sensory processing of pain intensity.
|
19116204 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This OPRM1 A118G-DPMS interaction is one plausible neurological mechanism underlying the individual differences in pain experience.
|
28057931 |
2017 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms in OPRM1 gene (opioid receptor, A118G), ABCB1 gene (opioid transporter, C3435T), COMT gene (pain sensitivity, G1947A), and UGT2B7 gene (opioid metabolism, -G840A) were tested.
|
25576257 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
µ-opioid receptor gene variant OPRM1 118 A>G: a summary of its molecular and clinical consequences for pain.
|
24236490 |
2013 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results indicate that among the genetic SNPs we studied which include those affecting analgesic drug metabolism, transport of analgesic agents across the blood-brain barrier, and their activity at target receptors and ion channels and in the modulation of neurotransmitter pathways, the A118G allele variant of OPRM1 has the most potent influence on pain management of postoperative patients.
|
25794200 |
2015 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Regarding the A118G SNP in exon 1, in a cold pressor-induced pain test before surgery, less analgesic effects of fentanyl were shown in subjects carrying the minor G allele of the A118G SNP (median of difference between pain perception latencies before and after fentanyl injection [PPLpost-PPLpre]: 12s) compared with subjects not carrying this allele (PPLpost-PPLpre: 15s, p=0.046).
|
19783098 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This discourages basing personalized therapeutic concepts of pain therapy on OPRM1 118A>G genotyping at the present state of evidence.
|
19683391 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain.
|
23803057 |
2013 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association was found between 118A>G and experimental pain
|
25239082 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients homozygous for the variant G allele of the 118 A > G polymorphism (n = 4) needed more morphine to achieve pain control, compared to heterozygous (n = 17) and homozygous wild-type (n = 78) individuals.
|
15504181 |
2004 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a subpopulation, identifying OPRM1 A118G polymorphism may provide valuable information regarding the individual analgesic doses that are required to achieve satisfactory pain control.
|
25102313 |
2014 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In comparison, two pain-related gene SNPs (OPRM1 [rs1799971] and COMT [rs4818]) interacted with psychological factors to predict four shoulder impairment phenotypes (abduction: 5-day average loss; strength loss: 5-day average, peak, and relative loss).
|
30425562 |
2018 |