|
rs1057518927
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1057518946
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs121908552
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1445287184
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1554781700
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555735545
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs28937900
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs397514698
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs781565158
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs61752717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of a homozygous M694V mutation was significantly associated with a more severe form of the disease: the clinical onset of the disease manifested at an earlier age; the number of attacks per month was higher; the global assessment by the treating physician and the severity of pain scored higher; and arthritis was more frequent.
|
10224214 |
1999 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli.
|
12595695 |
2003 |
|
rs6313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, T/T genotype of 102 T/C polymorphism may be associated with more severe pain in patient with IBS.
|
15232358 |
2004 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Patients homozygous for the variant G allele of the 118 A > G polymorphism (n = 4) needed more morphine to achieve pain control, compared to heterozygous (n = 17) and homozygous wild-type (n = 78) individuals.
|
15504181 |
2004 |
|
rs121913365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A1800T base exchange represented a novel mutation and resulted in a K600N transition in an AM from a 96-year-old white man who presented with rectal bleeding and painful sitting of a few weeks' duration.
|
15578519 |
2004 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study examines the association of the A118G SNP of OPRM1 to experimental pain sensitivity.
|
15772909 |
2005 |
|
rs104894379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous single base-pain substitution in exon 5 (408C --> A) was detected in all affected patients.
|
15823919 |
2005 |
|
rs1172682117
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous single base-pain substitution in exon 5 (408C --> A) was detected in all affected patients.
|
15823919 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (Val158Met) of COMT leads to a three to four fold reduction in the activity of the enzyme and has been associated to modifications in the response to a pain stressor.
|
15862471 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met polymorphism affects pain perception, and subjects with the Met/Met genotype have the most pronounced response to experimental pain.
|
15927391 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception.
|
16674809 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism.
|
16688411 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This suggests that the val(1</span>58)met SNP plays a primary role in variation in temporal summation of pai</span>n, but that other SNPs of the COMT haplotype exert a greater influence on resting nociceptive sensitivity.
|
16837133 |
2006 |
|
rs80338761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After confirming a heterozygous SEPT9 mutation (R88W) in the father and his mother, it became apparent that the dysmorphic features in the children were part of HNA and that previous complaints of the daughter, erroneously diagnosed as pronatio dolorosa and then epiphysiolysis of the capitellum humeri, were in fact a first neuralgic pain attack.
|
18492087 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism.
|
18548001 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia.
|
18719451 |
2008 |