|
rs6827096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the placebo group, SNPs rs165599 (COMT) was significantly associated with an increased heat pain threshold (β = -1.87; p = .003) and rs6827096 (EDNRA) with an increased resting pain (β = 2.68; p = .001).
|
31661578 |
2020 |
|
rs1050565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The <i>BLMH</i> rs1050565 G/G genotype was found to be associated with pain, and the <i>GSTP1</i> G/G genotype was linked infection (<i>p</i> < 0.05).
|
30914949 |
2019 |
|
rs1536309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CT/CC genotype of miR-146b rs1536309 was associated with the risk of pain symptom of endometriosis.
|
31122533 |
2019 |
|
rs16970540
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs showed suggestive associations with post-RT pain; rs16970540 in RFFL or near the LIG3 gene (p = 1.7 × 10<sup>-6</sup>), rs4584690, and rs7335912 in ABCC4/MPR4 gene (p = 5.5 × 10<sup>-6</sup> and p = 7.8 × 10<sup>-6</sup>, respectively), and rs73633565 in EGFL6 gene (p = 8.1 × 10<sup>-6</sup>).
|
31196165 |
2019 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-10 rs1800896 C allele is correlated with higher IL-10 levels in the plasma and the PBMC culture supernatant, which is associated with a higher pain threshold in the Chinese patients with IBS-D.
|
31205078 |
2019 |
|
rs1815739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Muscle biopsies, blood and pain scores were taken before and after the exercise to determine the extent of the exercise-induced damage and the effect of the ACTN3 R577X polymorphism.
|
30360698 |
2019 |
|
rs2070995
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing.
|
31269327 |
2019 |
|
rs2211843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046).
|
30760877 |
2019 |
|
rs28362731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AQP1 rs28362731 was significantly associated with thrombocytopenia (unadjusted: OR = 3.73, 95% CI = 1.00-13.84, P = 0.049; adjusted for pain: OR = 4.63, 95% CI = 1.13-19.05, P = 0.034) in additive model.
|
30840592 |
2019 |
|
rs3212361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results were validated in the 500,000-person U.K. Biobank (UKBB) cohort, where the minor alleles of rs3212361 and rs885479 were associated with a reduced count of persistent pain conditions as well as individual pain conditions.
|
31834199 |
2019 |
|
rs376128467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Taken together these data demonstrate gain-of-function attributes of the newly described N816K mutation at the channel and cellular levels, which are consistent with a pain phenotype in the carrier of this mutation.
|
31551682 |
2019 |
|
rs398655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KL variant, rs398655, interacted with self-reported pain in association with slowed epigenetic age (corrected p = 0.048).
|
30872092 |
2019 |
|
rs4584690
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs showed suggestive associations with post-RT pain; rs16970540 in RFFL or near the LIG3 gene (p = 1.7 × 10<sup>-6</sup>), rs4584690, and rs7335912 in ABCC4/MPR4 gene (p = 5.5 × 10<sup>-6</sup> and p = 7.8 × 10<sup>-6</sup>, respectively), and rs73633565 in EGFL6 gene (p = 8.1 × 10<sup>-6</sup>).
|
31196165 |
2019 |
|
rs6276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent depression-stratified analysis of rs6276 in DRD2 revealed that patients with the A/A genotype had higher pain scores than did those with the G/G genotype (P = 0.043).
|
30317684 |
2019 |
|
rs6311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphic allele of SNP rs6311 was more frequent in patients with severe pain (p:0.03).
|
30973927 |
2019 |
|
rs7335912
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs showed suggestive associations with post-RT pain; rs16970540 in RFFL or near the LIG3 gene (p = 1.7 × 10<sup>-6</sup>), rs4584690, and rs7335912 in ABCC4/MPR4 gene (p = 5.5 × 10<sup>-6</sup> and p = 7.8 × 10<sup>-6</sup>, respectively), and rs73633565 in EGFL6 gene (p = 8.1 × 10<sup>-6</sup>).
|
31196165 |
2019 |
|
rs73633565
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four SNPs showed suggestive associations with post-RT pain; rs16970540 in RFFL or near the LIG3 gene (p = 1.7 × 10<sup>-6</sup>), rs4584690, and rs7335912 in ABCC4/MPR4 gene (p = 5.5 × 10<sup>-6</sup> and p = 7.8 × 10<sup>-6</sup>, respectively), and rs73633565 in EGFL6 gene (p = 8.1 × 10<sup>-6</sup>).
|
31196165 |
2019 |
|
rs740603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Few associations replicated: morphine dose (mcg/kg) in African American children and ABCB1 rs1045642 (A allele, β = -9.30, 95% CI: -17.25 to -1.35, p = 0.02) and OPRM1 rs1799971 (G allele, β = 23.19, 95% CI: 3.27-43.11, p = 0.02); KCNJ6 rs2211843 and high pain in African American subjects (T allele, OR 2.08, 95% CI: 1.17-3.71, p = 0.01) and in congruent European Caucasian pain phenotypes; and COMT rs740603 for high pain in European Caucasian subjects (A allele, OR: 0.69, 95% CI: 0.48-0.99, p = 0.046).
|
30760877 |
2019 |
|
rs751416416
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype of rs4680 or A_T_C_A/ A_T_C_A (rs6269_rs4633_ rs4818_rs4680) diplotype of COMT, combined with the AG genotype of OPRM1 A118G, showed significantly increased pressure pain threshold from butorphanol.
|
31806881 |
2019 |
|
rs773030005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients with the COMT G472A-AA genotype (rs4680) and KCNJ6 A1032G-A allele (rs2070995) CLBP responded differently to opioid titration, with higher pain intensity requiring higher dosing.
|
31269327 |
2019 |
|
rs885479
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results were validated in the 500,000-person U.K. Biobank (UKBB) cohort, where the minor alleles of rs3212361 and rs885479 were associated with a reduced count of persistent pain conditions as well as individual pain conditions.
|
31834199 |
2019 |
|
rs1049353
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association between G1359A CB1 polymorphisms and pain in young northeastern Mexicans.
|
30371142 |
2018 |
|
rs121913274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next-generation sequencing analysis of 592 genes showed a missense mutation, p.E545A in PIK3CA, thus the patient was started on the mTOR inhibitor everolimus, in combination with exemestane, which controlled her pain; however, the disease progressed aggressively.
|
29790419 |
2018 |
|
rs12633508
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs13093031 and rs12633508 single-nucleotide polymorphisms (SNPs) near the LOC728432 gene region and rs6961071 SNP in the tcag7.1213 gene region were significantly associated with the analgesic effect of fentanyl, based on differences in pain perception latency before and after fentanyl administration.
|
29502940 |
2018 |
|
rs13093031
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs13093031 and rs12633508 single-nucleotide polymorphisms (SNPs) near the LOC728432 gene region and rs6961071 SNP in the tcag7.1213 gene region were significantly associated with the analgesic effect of fentanyl, based on differences in pain perception latency before and after fentanyl administration.
|
29502940 |
2018 |