Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2300478
rs2300478
MEIS1
G 0.820 GeneticVariation GWASDB Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs2300478
rs2300478
MEIS1
0.820 GeneticVariation BEFREE Case-control association studies showed significant association between all three variants and RLS (P=0.0001/OR=1.65, P=0.0021/OR=1.59, and P=0.0011/OR=1.55 for rs2300478, rs9357271, and rs1026732, respectively). 21925394

2011
dbSNP: rs4626664
rs4626664
PTPRD
0.820 GeneticVariation BEFREE A family-based sibling transmission disequilibrium test showed association of RLS with SNP rs1975197 (P = 0.015), but not with rs4626664 (P = 0.622). 21264940

2011
dbSNP: rs4626664
rs4626664
PTPRD
A 0.820 GeneticVariation GWASCAT PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. 18660810

2008
dbSNP: rs4626664
rs4626664
PTPRD
A 0.820 GeneticVariation GWASDB PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. 18660810

2008
dbSNP: rs2300478
rs2300478
MEIS1
G 0.820 GeneticVariation GWASCAT Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs2300478
rs2300478
MEIS1
G 0.820 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs3923809
rs3923809
BTBD9
A 0.820 GeneticVariation GWASCAT A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs3923809
rs3923809
BTBD9
A 0.820 GeneticVariation GWASDB A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs3923809
rs3923809
BTBD9
0.820 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs9296249
rs9296249
BTBD9
T 0.820 GeneticVariation GWASCAT Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs9296249
rs9296249
BTBD9
T 0.820 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs12593813
rs12593813
MAP2K5
0.810 GeneticVariation BEFREE However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033). 29422930

2018
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASDB Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASCAT Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs1975197
rs1975197
PTPRD
A 0.810 GeneticVariation GWASCAT Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs1975197
rs1975197
PTPRD
A 0.810 GeneticVariation GWASDB Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs1975197
rs1975197
PTPRD
0.810 GeneticVariation BEFREE Both family-based and population-based association studies suggest that PTPRD variant rs1975197 confers risk of RLS. 21264940

2011
dbSNP: rs6747972
rs6747972 		A 0.810 GeneticVariation GWASDB Herein, we identified six RLS susceptibility loci of genome-wide significance, two of them novel: an intergenic region on chromosome 2p14 (rs6747972, P = 9.03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767. 21779176

2011
dbSNP: rs6747972
rs6747972 		0.810 GeneticVariation BEFREE Herein, we identified six RLS susceptibility loci of genome-wide significance, two of them novel: an intergenic region on chromosome 2p14 (rs6747972, P = 9.03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767. 21779176

2011
dbSNP: rs6747972
rs6747972 		A 0.810 GeneticVariation GWASCAT Herein, we identified six RLS susceptibility loci of genome-wide significance, two of them novel: an intergenic region on chromosome 2p14 (rs6747972, P = 9.03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767. 21779176

2011
dbSNP: rs1975197
rs1975197
PTPRD
T 0.810 GeneticVariation GWASCAT PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. 18660810

2008
dbSNP: rs1975197
rs1975197
PTPRD
T 0.810 GeneticVariation GWASDB PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome. 18660810

2008
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASCAT Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007