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rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between single nucleotide polymorphisms (SNPs) in <i>CYP2R1</i> (rs10741657), <i>CYP27B1</i> (rs10877012), <i>DBP</i> (rs7041; rs4588), and <i>VDR</i> (rs2228570<i>)</i> genes and sarcoidosis, as well as the association between these SNPs and 25(OH)D levels in sarcoidosis patients.
|
31572458 |
2019 |
|
rs10877012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subjects carrying the CC genotype of <i>CYP27B1</i> rs10877012 have 10 times lower odds of suffering from sarcoidosis.
|
31572458 |
2019 |
|
rs4588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the A allele of the <i>DBP</i> gene (rs4588) was associated with lower levels of 25(OH)D in sarcoidosis patients.
|
31572458 |
2019 |
|
rs3177928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs were associated with sarcoidosis disease course (the strongest association with rs3177928, <i>P</i> = 0.003, OR = 1.9).
|
28469621 |
2017 |
|
rs9905945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main objective of this study was to expand the previous results and analyse combined influence of the found ACE SNP rs9905945 with the protective HLA markers HLADRB1* 03:01 and HLA-DRB1*04:01-DPB1*04:01 in 188 Finnish sarcoidosis patients (resolved disease, n = 90; persistent disease, n = 98).
|
29229112 |
2017 |
|
rs3775291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that TLR3 SNP rs3775291 may affect cardiac involvement in Japanese patients with sarcoidosis.
|
25720507 |
2015 |
|
rs2573351
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2 (rs1049550-rs2573351), the T-C haplotype occurred significantly less frequently (p=0.001), whereas the C-C haplotypes occurred more frequently (p=0.0001) in patients with sarcoidosis than controls.
|
25056970 |
2014 |
|
rs2819941
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant differences were found in the allelic or genotypic frequencies of the rs2789679, rs1049550 and rs2819941 in the ANXA11 gene between patients with sarcoidosis</span> and controls.
|
25056970 |
2014 |
|
rs6502976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The locus on chromosome 17p13.3-13.1 revealed a novel sarcoidosis risk SNP, rs6502976 (p = 9.5*10-6), within intron 5 of the gene X-linked Inhibitor of Apoptosis Associated Factor 1 (XAF1) that accounted for the majority of the admixture linkage signal.
|
24663488 |
2014 |
|
rs74318745
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Within the 6p24.3-p12.1 locus, the most significant ancestry-adjusted SNP was rs74318745 (p = 9.4*10-11), an intronic SNP within the HLA-DRA gene that did not solely explain the admixture signal, indicating the presence of more than a single risk variant within this well-established sarcoidosis risk region.
|
24663488 |
2014 |
|
rs1050045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs1050045 was significantly associated with sarcoidosis (corrected p=0.0215) in the validation panel and yielded a p-value of 9.22 × 10(-8) (OR 1.24) in the meta-analysis of the screening and validation stage.
|
22936702 |
2013 |
|
rs179008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The presence of the TLR7 rs179008/Gln11Leu polymorphism in sarcoidosis may determine an alteration of TLR7 function hampering the signaling pathway involved in the onset of both cellular and humoral autoimmunity.
|
24071890 |
2013 |
|
rs1799724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that the rs1799724 C/T polymorphism may affect susceptibility to cardiac sarcoidosis, while the rs1800871 T/C and rs1800872A/C polymorphisms may affect susceptibility to sarcoidosis with eye involvement.
|
24003533 |
2013 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the prevalence of rs1800871 and rs1800872 polymorphisms differed significantly in the sarcoidosis with eye involvement group compared with the control group [rs1800871 TT (vs. TC + CC): OR = 1.67, P = 0.034; rs1800872 AA (vs. AC + CC): OR = 1.66, P = 0.036].
|
24003533 |
2013 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that the rs1799724 C/T polymorphism may affect susceptibility to cardiac sarcoidosis, while the rs1800871 T/C and rs1800872A/C polymorphisms may affect susceptibility to sarcoidosis with eye involvement.
|
24003533 |
2013 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the prevalence of rs1800871 and rs1800872 polymorphisms differed significantly in the sarcoidosis with eye involvement group compared with the control group [rs1800871 TT (vs. TC + CC): OR = 1.67, P = 0.034; rs1800872 AA (vs. AC + CC): OR = 1.66, P = 0.036].
|
24003533 |
2013 |
|
rs2004640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype carrying rs10954213A and rs2280714A (haplotype 2) was significantly associated with susceptibility to sarcoidosis (OR = 2.00, 95% CI = 1.24-3.24, P = 0.004, corrected P = 0.01). rs729302 and rs2004640 were not associated with susceptibility to sarcoidosis, whereas carriage of rs2004640G was protective against pulmonary hypertension (OR = 0.017, 95% CI = 0.002-0.15, P < 0.001, corrected P < 0.001).
|
23288367 |
2013 |
|
rs4377299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for rs1049550, two additional novel ANXA11 sarcoidosis associations were identified only in African Americans--rs61860052 (odds ratio (OR)=0.62; 95% confidence interval (CI)=0.40-0.97) and rs4377299 (OR=1.31; 95% CI=1.06-1.63).
|
23151485 |
2013 |
|
rs4988453
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed a total of 93 cases with sarcoidosis and of 89 controls for the most common MyD88 SNPs: -938C>A (rs4988453) and 1944C>G (rs4988457).
|
23666053 |
2013 |
|
rs61860052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for rs1049550, two additional novel ANXA11 sarcoidosis associations were identified only in African Americans--rs61860052 (odds ratio (OR)=0.62; 95% confidence interval (CI)=0.40-0.97) and rs4377299 (OR=1.31; 95% CI=1.06-1.63).
|
23151485 |
2013 |
|
rs729302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype carrying rs10954213A and rs2280714A (haplotype 2) was significantly associated with susceptibility to sarcoidosis (OR = 2.00, 95% CI = 1.24-3.24, P = 0.004, corrected P = 0.01). rs729302 and rs2004640 were not associated with susceptibility to sarcoidosis, whereas carriage of rs2004640G was protective against pulmonary hypertension (OR = 0.017, 95% CI = 0.002-0.15, P < 0.001, corrected P < 0.001).
|
23288367 |
2013 |
|
rs745738344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis extended previous findings on the association between the TNF-α and TNF-β genetic polymorphisms and sarcoidosis, by showing that the TNF-β gene A252G polymorphism might be a potential risk factor for the development of sarcoidosis.
|
24244632 |
2013 |
|
rs11013452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotypic analyses of the C10ORF67-OTUD1 intergenic region revealed a strong inverse association of the variants rs1398024 and rs11013452 with sarcoidosis (odds ratio=0.52; P=0.01).
|
22972473 |
2012 |
|
rs1398024
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotypic analyses of the C10ORF67-OTUD1 intergenic region revealed a strong inverse association of the variants rs1398024 and rs11013452 with sarcoidosis (odds ratio=0.52; P=0.01).
|
22972473 |
2012 |
|
rs17235409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association between SA and four polymorphisms of the SLC11A1 gene, including a single nucleotide change in intron 4 (INT4); a nonconservative single-base substitution at codon 543 (D543N); a TGTG deletion in the 3' untranslated region; and the functional (GT)(n) repeat polymorphism in the 5' region, in 95 Turkish SA patients and 150 healthy controls, by using amplification refractory mutation system-polymerase chain reaction and sequencing.
|
22160516 |
2012 |